Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis

Table 5 Rare variants and polymorphisms of host restriction factors identified in HAM/TSP and ACs

Gene	Analysis	Frequency			Number of G-to-A mutations of HTLV-1 sequence
Gene	Analysis	HAM/TSP	ACs	p	Minor allele	Major allele	p
APOBEC3G	Rare variants	0.01	0.03	0.322	8.8 ± 4.1	6.5 ± 2.3	0.054
APOBEC3G	All	0.22	0.26	0.538	6.8 ± 2.2	6.4 ± 2.4	0.309
TRIM5α	Rare variants	0.05	0.00	0.035	5.2 ± 1.7	6.6 ± 2.4	0.157
TRIM5α	All	0.49	0.47	0.834	6.4 ± 2.3	6.6 ± 2.4	0.614

ISSN: 1742-4690