Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis

Table 1 Clinical findings, HTLV-1 subtype, proviral loads, and HTLV-1 sequence changes in patients of HAM/TSP and ACs

	f-HAM/TSP (n = 30)	s-HAM/TSP (n = 92)	ACs (n = 89)	p value
Age (years old)	54.7 ± 13.3	58.4 ± 13.2	52.7 ± 14.4	0.021
Male (N, %)	5, 17%	29, 32%	36, 40%	0.052
Transcontinental/Japanese subtype (n)	10/20	21/71	6/83	<0.001
Anti-HTLV-1 antibodies^e	20,992 ± 33,571 (N = 29)	30,707 ± 43,985 (N = 80)	7667 ± 17,209 (N = 80)	<0.001
HTLV-1 proviral loads (copies/10⁴ PBMCs)	819 ± 743	813 ± 936	366 ± 657	<0.001
No. of SNPs (reference AB513134)^a	34.2 ± 18.7	29.6 ± 19.2	22.3 ± 12.0	0.004
No. of SNPs (each reference)^b	21.4 ± 6.8	20.3 ± 7.5	19.5 ± 5.3	0.392
No. of G-to-A mutations (reference AB513134)^c	10.2 ± 4.6	8.9 ± 4.4	7.4 ± 3.2	0.003
No. of G-to-A mutations (each reference)^d	6.6 ± 2.5	6.3 ± 2.4	6.7 ± 2.2	0.422

Data are mean ± SD
f-HAM/TSP familial HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, s-HAM/TSP sporadic HAM/TSP patients, ACs asymptomatic HTLV-1 carriers
^aNumber of SNPs of complete HTLV-1 sequences using the data mapped to AB513134
^bNumber of SNPs of complete HTLV-1 sequences using the data mapped to each reference; transcontinental subtype, consensus transcontinental reference; Japanese subtype, AB513134
^cNumber of G-to-A mutations of complete HTLV-1 sequences using the data mapped to AB513134
^dNumber of G-to-A mutations of complete HTLV-1 sequences using the data mapped to each reference; transcontinental subtype, consensus transcontinental reference; Japanese subtype, AB513134
^eParticle aggregation method

ISSN: 1742-4690