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Fig. 2 | Retrovirology

Fig. 2

From: Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

Fig. 2

APOBEC3/Rfv3 inhibits acute FV infection of splenocytes independent of type I IFN signaling. Splenocyte FV infection levels were measured by flow cytometry using a glyco-gag specific monoclonal antibody. a Representative flow plots showing glyco-gag+ splenocytes from FV/LDV infected mice at 7 dpi. The percentage of live splenocytes that expressed glyco-gag was evaluated in b FV/LDV and c LDV-free FV infections. Each dot corresponds to a mouse and lines correspond to mean values. The total number of mice analyzed was combined from 2 to 3 independent experiments. Fold-change of mean values per cohort are shown. Data were analyzed using a 2-tailed unpaired Student’s t test, with exact p values shown

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