Inhibition of human endogenous retrovirus-K by antiretroviral drugs

Retrovirology

Table 1 Comparison of HIV and HERV-K IC90 values for antiretroviral drugs

Antiretroviral drugs	HIV IC₉₀	HERV-K IC₉₀ (µM)	HERV-K IC₅₀ (µM)
Abacavir	2.3 µM	0.175	0.006
Zidovudine	0.03 µM	0.070	0.008
Darunavir	2.7–13 nM	0.071	0.029
Lopinavir	IC₅₀ 17 nM (no serum) IC₅₀ 102 nM (50% serum)	0.651	0.034
Raltegravir	0.033 µM	0.075	0.01

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