Fig. 8
From: Inhibition of human endogenous retrovirus-K by antiretroviral drugs
Comparative modeling of HERV-integrase active site. a Model of the integrase with the DNA bound. b Alignment between target and template was used in the modeling; red boxed residues are identical. c–e The integrase inhibitors mentioned bound to HERV-K integrase active site: a Elvitegravir, b Raltegravir were based on the crystal structure of their complexes of PFV (3L2U, 3L2V), and c Dolutegravir. Carbon atoms of the enzyme residues are colored green when they are conserved between PFV and HERV-K integrase and red when are not. DNA bases have their carbon atoms colored cyan