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Fig. 8 | Retrovirology

Fig. 8

From: Inhibition of human endogenous retrovirus-K by antiretroviral drugs

Fig. 8

Comparative modeling of HERV-integrase active site. a Model of the integrase with the DNA bound. b Alignment between target and template was used in the modeling; red boxed residues are identical. ce The integrase inhibitors mentioned bound to HERV-K integrase active site: a Elvitegravir, b Raltegravir were based on the crystal structure of their complexes of PFV (3L2U, 3L2V), and c Dolutegravir. Carbon atoms of the enzyme residues are colored green when they are conserved between PFV and HERV-K integrase and red when are not. DNA bases have their carbon atoms colored cyan

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