Fig. 4
From: Inhibition of human endogenous retrovirus-K by antiretroviral drugs
Comparative modeling of HERV-K reverse transcriptase (RT) based on HIV RT. a Sequence alignment between the target and the template (4WE1). b Final Model of HERV-K RT showing P51 and P66 subunits. The red oval indicates the NNRTI-binding region. c–e Efavirenz, Nevirapine, and Etravirine, respectively bound to the NNRTI-binding pocket. Non conserved residues are colored red, green the conserved between HERV-K and HIV-1 RT. The NNRTIs are colored with their carbon atom in magenta. The magenta underlined sequence are residues lining the NNRTI-binding pocket