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Fig. 7 | Retrovirology

Fig. 7

From: DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas

Fig. 7

CpG methylation and hydroxymethylation profiles of the ERVWE1 promoter in selected samples. To analyze CpG modifications of the ERVWE1 promoter (5′LTR), bisulfite together with oxidative bisulfite sequencing were applied. Results of the bisulfite sequencing (5-mC + 5-hmC) are shown in the left part of the picture, results of the oxidative bisulfite sequencing (5-mC) in the right part of the picture. Analysis of the promoter molecules is shown as a linear array of open circles representing non-modified CpG residues and closed circles representing methylated or hydroxymethylated CpG residues. Each line represents one sequenced molecule of the 5′ LTR. The mean percentage of modified CpGs is presented for each sample. Schematic representation of the CpG dinucleotide distribution in the ERVWE1 promoter together with primers used for the analysis is shown at the bottom. Significance was assigned as follows: *** for P-values <0.001, ** for P-values <0.01

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