Skip to main content
Fig. 7 | Retrovirology

Fig. 7

From: HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells

Fig. 7

Biochemical GTPase activation assay reveals HIV significantly activates Rac1 and Cdc42. Primary CD4+ T cells were exposed to CCR5-tropic HIV-1 or microvesicles for 1 min and then assessed for RhoA, Rac1, or Cdc42 activation using a small GTPase activation assay (G-LISA). Results were normalized to the microvesicle controls to determine fold-changes in activation. The mean and SD of 6 independent experiments are shown

Back to article page

Retrovirology

ISSN: 1742-4690

Contact us