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Fig. 5 | Retrovirology

Fig. 5

From: HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells

Fig. 5

Inhibition of the Rho family GTPases RhoA and Cdc42 and the Rho-associated protein kinase (ROCK) reduce HIV infection. Primary CD4+ T cells were infected with CXCR4-tropic reporter viruses following treatment with small molecule inhibitors targeting a Rho A/C signaling, b Rho family member Cdc42, and c Rho-kinase Rock decrease HIV LTR-driven EGFP expression. *p < 0.05, **p < 0.01, ***p < 0.001. All experimental conditions performed in triplicate. Error bars represent SEM

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