Memory CD4+ T cells | Myeloid cells | Dendritic cells | FDCs | Epithelial cells | |||
---|---|---|---|---|---|---|---|
Monocytes | Macrophages | pDCs | mDCs | ||||
Available VOA? | Yes (gold standard) [23] | Yes [24] | Yes [25] | No | No | Yes [26] | No |
Has VOA been applied to PLWH taking long-term ART? | Yes (gold standard) [18] | No | Yes [25] | NA | NA | Yes [26] | No |
Has HIV-1 been demonstrated in the indicated cell type in PLWH taking long-term ART? | Yes (gold standard) [18] | No | Yes [25] | NA | NA | Yes [26] | Yes |
Is HIV in this reservoir replication competent? | Yes (gold standard) [18] | NA | No | NA | NA | Yes [26] | NA |
Available animal models? | Yes [27] | Yes [24] | Yes [24] | Yes [24] | Yes [24] | Yes [27] | No |
Have animal models been studied during long-term ART? | Yes [28] | No | No | No | No | No | No |
Do animal models with suppressed viremia contain replication competent HIV-1? | Yes [28] | NA | NA | NA | NA | NA | NA |
Longevity or T½ of uninfected cells | 2–3 days [31] | ≥24–36 months [32]b | ? | ? | ? | ? | |
Longevity or T½ of reservoir in this cell type | 44 months [18]a | NA | ? | ? | ? | 9 months [33]c | ? |