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Table 5 Frequency of resistance mutations in donors failing anti-retroviral therapy as measured by uSGS

From: Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA

Allele

Donor 1 Sample 1

% Frequency

(1585 uSGS)

Donor 1 Sample 2

% Frequency

(675 uSGS)

Donor 2 Sample 3

% Frequency

1227 (uSGS)

D67N

100

99.85

99.92

T69A

<0.06

0.15

0.08

T69I

0.06

<0.15

<0.08

K70N

<0.06

<0.15

0.08

K70Q

<0.06

<0.15

1.07

K70T

<0.06

<0.15

1.23

L74I

<0.06

<0.15

0.08

K101E

95.56

95.72

<0.08

K101Q

4.12

3.99

0.08

K101R

<0.06

<0.15

0.49

V106I

91.12

91.58

0.33

V108A

<0.06

<0.15

0.08

V108I

0.51

<0.15

0.41

M184I

<0.06

<0.15

0.16

M184V

<0.06

<0.15

99.84

Y188C

0.06

<0.15

<0.08

G190A

99.81

100

<0.08

G190E

<0.06

<0.15

0.08

G190R

<0.06

<0.15

0.08

G190T

0.13

<0.15

<0.08

T215F

0.06

<0.15

<0.08

T215R

<0.06

<0.15

<0.08

T215Y

99.94

100

100

K219R

99.94

99.85

<0.08