Fig. 2

Visualization of the model coefficients for the V3 loop of the mutant ROD10 isolate (H18L + K29T). Amino acids with positive coefficients are associated with R5-tropic viruses, while negative coefficients are associated with X4-capable variants. The legend on the right indicates the color-coded amino acids and gives the FPR of the prediction. Because the predicted FPR is below the selected cutoff at 5%, the sequence is predicted to be X4-capable, which is indicated by the dark color of the X4-capable label in the bottom left corner. The labels of the x-axis refer to the positions and amino acids of the HIV-2 reference strain M33262. Note that since the input sequence contains two insertions relative to the reference (H and Y after position 22), the 29T mutation is visualized at the x-axis tick with the D27 label