Fig. 1

X4-probabilities predicted by geno2pheno[coreceptor-hiv2] for V3 amino-acid sequences exhibiting the established discriminatory features indicative of X4-capability listed on the x-axis. The left-hand panel shows the predicted X4-probabilities for sequences labeled as R5, while the right-hand panel shows the predicted X4-probabilities for sequences labeled as X4-capable. The bottom line of a box indicates the 1st quartile (Q1) of predicted X4-probabilities, the bar inside the box indicates the median, and the top line indicates the 3rd quartile (Q3). The whiskers extending from a box indicate predicted X4-probabilities that lie within 1.5× IQR (interquartile range, IQR = Q3 − Q1). Outlier values that are not within the whisker region are shown as dots. Note that some of the sequence characteristics indicated on the x-axis do not have a predicted X4-probability, because no sequences exhibiting the corresponding feature and phenotype were available