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Fig. 5 | Retrovirology

Fig. 5

From: First Phase I human clinical trial of a killed whole-HIV-1 vaccine: demonstration of its safety and enhancement of anti-HIV antibody responses

Fig. 5

SAV001 elicits antibodies that recognize HIV-1 envelope glycoproteins at the surface of infected cells. CEM.NKr cells infected with full-length NL4.3 GFP ADA Env (WT) (a, c, e and g) or deleted for nef and vpu (N-U-) (b, d, f and h) were stained at 48 h post-infection with 1/1000 dilution of HIV + sera from Placebo- (a and b), Placebo + Adjuvant- (c and d), SAV001- (e and f) or SAV001 + Adjuvant- (g and h) vaccinees and then fluorescently labeled with an Alexa-Fluor-647 conjugated anti-human IgG secondary Ab [27, 28, 36]. Shown is the mean fluorescent intensity (MFI) of staining by sera from study participants. Statistical significance was tested using a paired t test (*p < 0.05)

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