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Fig. 2 | Retrovirology

Fig. 2

From: TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes

Fig. 2

R848 induces a SAMHD1-independent block to infection of monocytes. a Monocytes from 2 healthy donors were treated for 24 h with 10 µM R848 or 100 U/mL IFNα and then infected with Vpx-containing HIV-1 (HIV1 X+). After 24 h, lysates were prepared and SAMHD1 was quantified by immunoblot analysis with a GAPDH loading control. b BMDC from two SAMHD1 knock-out mice (one bar per mouse) were treated for 24 h with (blue) or without 10 µM R848 and then infected with HIV-1 luciferase reporter virus (HIV1) in the presence or absence of Nevirapine (NVP). Luciferase activity was measured after 72 h

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