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Fig. 6 | Retrovirology

Fig. 6

From: Antibody-dependent CD56+ T cell responses are functionally impaired in long-term HIV-1 infection

Fig. 6

ADCC activity mediated by CD56+ T cells were mainly ascribed to CD4/CD8 double negative subset. a CD56+ T cells were divided into three subsets: CD4+ CD8−, CD4− CD8+, and CD4− CD8− (double negative, DN) subsets. Representative flow plots from a HIV-infected individual and a healthy donor were shown. b Frequencies of different CD56+ T subsets in HIV-1+ (n = 10) and healthy (n = 10) subjects. c, d ADCC activities mediated by CD56+ T subset from HIV-1+ and healthy subjects were evaluated and compared. CD107a expression (c) and IFNγ production (d) of CD4+ CD8−, CD4− CD8+, and DN subset activated by Ab-bound P815 cells in HIV-1+ (n = 10) and healthy (n = 10) subjects were compared. e Comparison of CD16+ cells in individual CD56+ T subsets in HIV-1+ and healthy subjects. f Loss of CD16 MFI on different CD56+ T subsets in HIV-1+ and healthy subjects. g Expressions of NKG2A, NKG2C, NKG2D, NKp44 and NKp46 on three CD56+ T subsets from ten healthy subjects. MFI mean fluorescence intensity. bg Data were showing as mean ± SD

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