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Table 1 Representative neutralization data of JRFL and JRCSF pseudotyped viruses [3, 34, 38]

From: Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes

mAb epitope mAb JRFL JRCSF
CD4-bs b12 +++ ++
  VRC01 +++ ++
  NIH45-46 ++++ +++
  CH103 ++++ +++
  3BNC117 ++++ +++
  8ANC131 +++ ++
CD4i 17b
V1V2V3 glycan-dependent PG9 ++++
  PG16 ++++
  PGT145 + ++++
  PGT121 +++ +++
  PGT128 ++++ ++++
  2G12 + ++
MPER 10E8 ++ ++
  4E10 + +
  2F5 + +
FP VRC34 + ±
  1. + IC50: 1–10
  2. ++ IC50: 0.1–1
  3. +++ IC50: 0.01–0.1
  4. ++++ IC50: <0.01
  5. − IC50 > 50