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Fig. 8 | Retrovirology

Fig. 8

From: Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes

Fig. 8

Mutation of REKR cleavage sequence to SEKS in JRCSF exposes non-neutralizing epitopes. Comparative binding of JRCSF and JRCSF (SEKS) to neutralizing Abs 2G12 and PGT121 and non-neutralizing Abs F105, b6 and 39F over a range of antibody concentrations by FACS-based cell surface staining assay

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Retrovirology

ISSN: 1742-4690

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