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Fig. 6 | Retrovirology

Fig. 6

From: Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes

Fig. 6

N197D mutation in JRCSF restores CD4-bs-directed bNAb binding to JRCSF. a FACS-based cell surface staining assay of JRFL, JRCSF and the mutants C2, N197D, N230D, N289K (all in JRCSF) with 2G12 and b12 over a range of antibody concentrations. b FACS-based cell surface assay of JRFL, JRCSF and the mutant JRCSF (N197D) with VRC01 over a range of antibody concentrations

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