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Fig. 5 | Retrovirology

Fig. 5

From: Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes

Fig. 5

Domain swapping experiments to determine minimal region of JRFL, which confers CD4-bs-directed bNAb binding on JRCSF. a Schematic representation of domain swapped mutants. b–d FACS-based cell surface staining assay of JRFL, JRCSF and domain swapped mutants with the neutralizing Abs 2G12, VRC01, b12 and the non-neutralizing Ab F105 over a range of antibody concentrations

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Retrovirology

ISSN: 1742-4690

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