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Fig. 3 | Retrovirology

Fig. 3

From: Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes

Fig. 3

Comparative binding of JRFL, JRCSF and JRFL (E168K) to V2 “cap” targeted glycan and conformation-dependent Abs PG9 and PGT145 over a range of antibody concentrations by FACS-based cell surface staining assay. The bar diagram represents the binding of the respective antibodies to wild type and mutant Envs at 20 µg/ml of antibody concentration

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Retrovirology

ISSN: 1742-4690

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