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Table 1 Residual entry of selected HIV-1 subtype C Envs in the presence of MVC in NP2-CD4/CCR5 and 293-Affinofile CD4med/CCR5hi cells

From: Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

Patient ID

Env clone

Residual entry in NP2 cells (%)a

Residual entry in Affinofile cells (%)a

 

ADA

0.25 ± 0.04

n.a.

YU2

0.04 ± 0.02

0.26 ± 0.02

JRCSF

0.09 ± 0.02

0.18 ± 0.02

MVCres

37.8 ± 1.01

68.45 ± 14.35

MVCsens

1.82 ± 0.2

47.28 ± 2.23

204

E-7

3.6 ± 0.09

36.24 ± 5.01

550

I-2

3.80 ± 0.71

52.6 ± 13.87

I-7

3.84 ± 1.00

36.2 ± 1.81

F-12

4.32 ± 1.32

60.32 ± 7.20

F-20

2.80 ± 1.11

38.83 ± 4.09

1375

E-2

9.73 ± 2.50

84.20 ± 8.99

I-8

20.34 ± 5.23

69.03 ± 9.10

1441

E-1

5.70 ± 0.47

44.77 ± 2.55

E-2

2.7 ± 1.00

53.69 ± 9.14

E-6

6.72 ± 0.66

67.26 ± 9.58

I-2

3.90 ± 0.49

68.34 ± 11.52

I-9

4.57 ± 0.42

79.78 ± 4.18

1503

F-7

3.37 ± 0.71

n.a.

1684

E-7

2.84 ± 1.74

27.46 ± 3.51

1854

I-7

4.56 ± 0.73

n.a.

2042

I-38

2.95 ± 0.86

38.77 ± 0.53

  1. n.a. not done
  2. aMean % residual entry ± standard deviation from two independent experiments