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Fig. 6 | Retrovirology

Fig. 6

From: Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

Fig. 6

V3 loop mutations are necessary but not sufficient for incomplete MVC inhibition phenotypes of HIV-1 subtype C Envs. Luciferase reporter viruses pseudotyped with parental and mutant Envs from subjects 1375 and 1441 were used to infect 293-Affinofile CD4med/CCR5hi cells in the presence of increasing concentrations of MVC. Virus inhibition curves were constructed as described in the “Methods”. The data points represent the mean and standard error of triplicate wells from one representative experiment of three independent experiments

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