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Fig. 3 | Retrovirology

Fig. 3

From: Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

Fig. 3

The level of incomplete HIV-1 inhibition by MVC in subtype C Envs is dependent on the efficiency of interaction with MVC-bound CCR5. Luciferase reporter viruses from subjects 1684 (a) and 1375 (b) were used to infect 48 differentially-induced 293-Affinofile cell populations in the presence and absence of 10 μM MVC as described in the “Methods”. The percent infectivity was normalized that achieved in 293-Affinofile cells induced to express the maximal amount of CD4 and CCR5. The data shown are means of duplicate infections and are representative of three independent experiments

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