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Table 3 Recovery of integrated viral DNA from cells infected with the IN mutant N155H

From: Drug resistant integrase mutants cause aberrant HIV integrations

Cell type, drug concentration Aberrant integration Normal integration % Aberrant integration 1-LTR (aberrant 1-LTR) 2-LTR (aberrant 2-LTR) Autointegrants (aberrant circles) Total no. of samples recovered and sequenced
HOS
 No drug 5 36 12.2 82 (8) 27 (17) 4 (66) 287
 RAL IC50 6 26 18.7 75 (15) 55 (23) 6 (43) 288
 RAL IC75 2 6 25 93 (7) 57 (22) 5 (55) 288
PBMC
 No drug 10 103 8.8 82 (4) 15 (1) 0 (36) 285
  1. RAL IC50: 297 nM