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Table 3 Recovery of integrated viral DNA from cells infected with the IN mutant N155H

From: Drug resistant integrase mutants cause aberrant HIV integrations

Cell type, drug concentration

Aberrant integration

Normal integration

% Aberrant integration

1-LTR (aberrant 1-LTR)

2-LTR (aberrant 2-LTR)

Autointegrants (aberrant circles)

Total no. of samples recovered and sequenced

HOS

 No drug

5

36

12.2

82 (8)

27 (17)

4 (66)

287

 RAL IC50

6

26

18.7

75 (15)

55 (23)

6 (43)

288

 RAL IC75

2

6

25

93 (7)

57 (22)

5 (55)

288

PBMC

 No drug

10

103

8.8

82 (4)

15 (1)

0 (36)

285

  1. RAL IC50: 297 nM