Skip to main content

Table 1 Recovery of integrated viral DNA from elvitegravir treated cells

From: Drug resistant integrase mutants cause aberrant HIV integrations

HOS cells; drug concentration Aberrant integration Normal integration % Aberrant integration 1-LTR (aberrant 1-LTR) 2-LTR (aberrant 2-LTR) Autointegrants (aberrant circles) Total no. of samples recovered and sequenced
No drug* 0 99 0 7 (0) 0 (0) 1 (2) 120
IC14** 4 39 9.3 108 (21) 19 (5) 10 (56) 288
IC30 1 14 6.6 102 (31) 10 (8) 11 (58) 276
IC50 2 19 9.5 116 (18) 28 (14) 11 (47) 288
IC60 2 19 9.5 125 (11) 26 (10) 12 (52) 288
IC75 8 46 14.8 93 (25) 13 (13) 3 (57) 287
  1. * Data for the no drug control are from Varadarajan et al. [10]
  2. ** EVG IC50: 6.57 nM