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Table 1 Recovery of integrated viral DNA from elvitegravir treated cells

From: Drug resistant integrase mutants cause aberrant HIV integrations

HOS cells; drug concentration

Aberrant integration

Normal integration

% Aberrant integration

1-LTR (aberrant 1-LTR)

2-LTR (aberrant 2-LTR)

Autointegrants (aberrant circles)

Total no. of samples recovered and sequenced

No drug*

0

99

0

7 (0)

0 (0)

1 (2)

120

IC14**

4

39

9.3

108 (21)

19 (5)

10 (56)

288

IC30

1

14

6.6

102 (31)

10 (8)

11 (58)

276

IC50

2

19

9.5

116 (18)

28 (14)

11 (47)

288

IC60

2

19

9.5

125 (11)

26 (10)

12 (52)

288

IC75

8

46

14.8

93 (25)

13 (13)

3 (57)

287

  1. * Data for the no drug control are from Varadarajan et al. [10]
  2. ** EVG IC50: 6.57 nM