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Fig. 5 | Retrovirology

Fig. 5

From: Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors

Fig. 5

Comparison of infectivity and envelope content among fusion inhibitor-resistant mutants. a The infectivity levels of ENF-resistant mutants, V38A, N43D, and Q40H, and of C34-resistant mutants, I37K, N126K, L204I, I37K/N126K, I37K/L204I, N126K/L204I, and C34r, are shown. The TCID50 and p24 concentrations were determined by single round infection assays using TZM-bl cells and ELISAs, respectively. Infectivity is shown as the TCID50/p24 amount ratio. b The envelope content per virion was compared among C34 resistance mutants. The concentrations of envelope and p24 in pseudovirus stocks were determined by ELISAs. As negative control pseudovirus expressing no envelope was used. The envelope content is shown as the envelope/p24 amount ratio. The results are expressed as the means ± SEs of three independent experiments. Asterisks correspond to values that are statistically different from those of the WT (p < 0.05 as calculated using the Mann–Whitney U test)

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