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Fig. 4 | Retrovirology

Fig. 4

From: Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors

Fig. 4

Binding of antibodies to untriggered envelope trimers. The effect of fusion inhibitor resistance-conferring mutations on the binding of anti-CD4bs MAbs, VRC01, 49G2, and 42F9, and of anti-V3 MAbs, KD247, 16G6, and 0.5γ, was determined by performing flow cytometry on 293T cells expressing mutant envelopes. The geometric MFI was calculated and normalized by the MFI of 2G12. The changes in antibody binding levels are presented as the fold change of binding with respect to WT. The dash line represents the change in antibody binding (fold change = 1). The results are shown as the means ± SEs of three replicas

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