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Fig. 4 | Retrovirology

Fig. 4

From: Type I interferon responses are impaired in latently HIV infected cells

Fig. 4

IFNα-induced PKR expression was impaired in latently HIV-infected OM10.1 cells. Cell lines were left unstimulated or treated with increasing concentrations of exogenous IFNα for 24 h. Following stimulation, cells were fixed and permeabilized, after which intracellular PKR expression was measured by flow cytometry. Representative histogram and cumulative summary of IFNα-induced PKR expression, normalized to unstimulated controls, is shown for a U937 and U1 cells (n = 6) and b HL60 and OM10.1 cells (n = 6). p = 0.04; p = 0.0008; § p < 0.0001 by one-way ANOVA and p < 0.05 by pairwise Dunnett’s Test compared to unstimulated cells. *p < 0.05; **p < 0.001 by Two-way ANOVA with Bonferroni post-test for multiple comparisons

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