Fig. 1
From: Type I interferon responses are impaired in latently HIV infected cells
Expression of IFNAR1, MHC-I, ISG15, and PKR in HIV-uninfected and latently HIV-infected cells. Constitutive expression of several ISGs was quantified by flow cytometry in latently HIV-infected U1 and OM10.1 cells. Surface expression of a IFNAR1 (n = 5) and b MHC-I (n = 6) were significantly lower in the latently HIV-infected U1 and OM10.1 cells, than in uninfected parental controls. c Constitutive intracellular expression of ISG15 (n = 6) was minimal in all cell lines. d Intracellular PKR expression was higher in latently HIV-infected OM10.1 cells, than in uninfected HL60 cells (n = 6). No difference in basal PKR expression was observed between U937 and U1 cells (n = 6). Representative histogram and cumulative data for each ISG is shown. *p < 0.0001, **p = 0.002, ***p < 0.0017 by unpaired T test