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Table 6 HERV-W loci homology of previously described MSRV sequences and probes

From: Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes

MSRV GenBank entry

HERV-W locus/loci

Query cover

n° of discordant bases

Mapped portion in LTR17-HERV17-LTR17

AF127227 (544 bp)

3q23a* (99.5 %)

1–544

3

env (8208–8752)

AF127228 (1932 bp)

Xq22.3b* (99.6 %)

1–1932

9

pol-env (5444–5838 and 7682–9200)

AF127229 (2004 bp)

3p12.3* (99.9 %)

1–1084

2

pol-env-3′ LTR (5452–6792 and 8290–8318 and 9115–9732)

18q21.32* (99.9 %)

1055–2004

2

AF123882 (2477 bp)

12q21.3* (99.8 %)

1–2477

7

pol-env (5720–8199)

AF331500 (1629 bp)

Xq22.3b* (99.7 %)

1–1332

4

env (7720–9348)

5p12* (99.4 %)

1308–1629

2

AF123881 (1511 bp)

3q26.32* (99.9 %)

1–1511

2

gag-pro (2765–4269)

AF009668 (2304 bp)

1p34.2 (99.1 %)

1–633

6

pro-pol (4178–6480)

2p12a (100 %)

623–736

0

2p24.2 (100 %)

717–871

0

6q27b (98.5 %)

837–1424

11

6q15 (97.2 %)

1415–1763

10

3p12.3 (99.4 %)

1719–2304

4

AF009666 (324 bp)

1p34.2 (99.5 %)

1–324

3

pro-pol (4178–4521)

AF009667 (118 bp)

17q22 (98.2 %)

1–118

2

pol (5031–5148)

AF123880 (1003 bp)

5p12 (99.6 %)

1–203

1

5′ LTR (255–803)

3p24.1 (100 %)

198–593

1

3q26.32 (98 %)

592–1003

11

AF072494 pol probe (678 bp)

6q21b (99.6 %)

1–678

5

pol (4660–5338)

AF072496 gag probe (536 bp)

6q21b (99.6 %)

1–536

2

pre gag-gag(2706–3199)

AF072497 pro probe (364 bp)

1p34.2 (99.2 %)

1–364

4

pro-pol (4166–4522 and 5641–5549)

AF072498 env probe (591 bp)

Xq22.3b (99.5 %)

1–591

3

env (8606–9196)

  1. Previously published MSRV sequences and probes (column 1) were analyzed for their homology to one/more HERV-W locus/loci by BLAT search, considering the best match in human genome (reported in column 2 near to each HERV-W element). The MSRV elements portion similar to HERV-W locus/loci (column 3) as the number of discordant nucleotides with respect to the identified HERV-W locus/loci (column 4) and the correspondent positions in the LTR17-HERV17-LTR17 reference (column 5) were obtained through Mafft alignment and Geneious platform analysis. MSRV sequences were characterized through the analysis of each element with respect to the whole HERV-W dataset with Recco software
  2. * Already investigated by Laufer et al. [89]
  3. ° 95 % similarity with AF135487, a retroviral-related sequence reported to be schizophrenia associated and mapped to multiple sites