Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes

Table 4 HERV-W genomic context: transcription factor (TF) binding sites

HERV-W	TF recognized	Position	Score (0–1000)
2p12a*	POLR2A	chr2:76098843–76099352	803
2q22.2*	E2F1	chr2:143661226–143661546	958
3p22.2*	CTCF	chr3:38331061–38331485	900
4p16.1*	POLR2A	chr4:8429472–8430544	1000
4p16.1*	TCF7L2	chr4:8424096–8424592	922
6p12.2*	TFAP2C	chr6:52783052–52783485	1000
	FOXA2	chr6:52783244–52783462	848
	STAT3	chr6:52784270–52784579	808
6q14.3*	STAT3	chr6:85427859–85428174	1000
6q14.3*	CEBPB	chr6:85427862–85428118	817
7q21.1*	TCF7L2	chr7:92103429–92103733	1000
7q31.1a	TCF7L2	chr7:107981247–107981830	1000
7q31.1a	E2F1	chr7:107981308–107981897	1000
7q33*	YY1	chr7: 34270591–134271127	1000
7q36.1*	FOXA1	chr7:149370177–149370408	1000
9q22.1	TCF7L2	chr9:91556701–91556965	1000
10q21.2*	GATA3	chr10:62797340–62797529	1000
10q21.2*	E2F1	chr10:62796837–62797697	806
10q23.1*	GATA1	chr10:86284672–86285183	1000
	MAFK	chr10:86285572–86285911	1000
	MAFF	chr10:86285647–86285793	1000
	TBL1XR1	chr10:86284785–86285185	824
10q24.1	TAL1	chr2:97480654–97480806	928
10q24.1	TEAD4	chr10:97480630–97480810	859
10q21.3	MAFK	chr10:65805045–65805364	1000
21q21.1*	TFAP2C	chr21:20128637–20128925	1000
21q21.1*	YY1	chr21:20131977–20132464	859

Data obtained from Genome Browser Encode Transcription Factor ChIP-seq database
Proviruses and undefined sequences are labeled respectively with * and °. Bold loci are the one inserted into human genes

ISSN: 1742-4690