Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs

Retrovirology

Table 2 Pairwise pol distance, env population distance and diversity along with infection stage of transmission pairs

Pair	pol distance (%)	No. of env sequences		env distance (%)	env diversity (%)		Infection stage
Pair	pol distance (%)	T	R	env distance (%)	T	R	T	R
T1–R1	0.24	28	23	1.45	3.05	0.26	Chronic	Acute
T2–R2	0.48	21	27	2.45	4.61	0.18	Chronic	Acute
T3–R3	0.71	20	11	1.49	3.37	0.10	Chronic	Acute
T4–R4	0.48	30	10	0.85	1.69	0.07	Chronic	Acute
T5–R5	0.23	18	19	0.28	0.93	0.22	Chronic	Acute
T6–R6	0.24	25	18	0.11	0.51	0.34	Recent	Acute
T7–R7	0.15	5	18	0.12	0.34	0.12	eART-STI^b	Acute
T8–R8	0.08	17	19	0.32	0.50	0.11	eART-STI^b	Acute
T9–R9	0.16	5^a	8	1.40	1.08	0.35	Recent	Acute

T transmitter, R recipient
^aSequences of T9 are derived from full-length env clones only after several SGA attempts failed
^b Early antiretroviral treatment (eART) was started immediately after infection and HIV-1 was transmitted upon virus rebound after structured treatment interruption (STI)

ISSN: 1742-4690