Fig. 6

Transmitter and recipient viruses have comparable cell–cell transmission and free virus infection capacities. a Cell–cell transmission and b free virus infection of transmitter (red) and recipient (blue) Env-pseudoviruses are shown. For cell–cell transmission pseudovirus transfected 293-T cells (gaussia luciferase reporter NLinGluc) and for free virus infection 293-T derived pseudovirus (firefly luciferase reporter NLluc-AM) were used. A3.01-CCR5 served as target cells. Mean and standard deviation from three to six experiments each performed in triplicates are shown. Statistical significance between transmitter virus median values and recipient viruses was tested with a Wilcoxon matched-pairs signed rank test