Fig. 3

Transmitter and recipient viruses exhibit no difference in sensitivity to neutralizing antibodies and entry inhibitors. Inhibition of transmitter and recipient Env-pseudoviruses by a gp120 directed, gp41 directed and b cell directed inhibitors in TZM-bl assays. Transmitter (T) and recipient (R) 50 % inhibitory concentration (IC₅₀) values in μg/ml are depicted and IC₅₀ values above the highest concentration tested (indicated by the dotted line) were given an arbitrary value of 30. Transmission pairs are connected with a line. N specifies the number of Env-pseudoviruses (out of 26) with an IC₅₀ value below the highest inhibitor concentration tested and the p values were determined by the Wilcoxon matched-pairs signed rank test. Values were derived from 2 independent experiments each performed in duplicates. For detailed IC₅₀ values see Additional file 9: Table S4