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Fig. 4 | Retrovirology

Fig. 4

From: The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility

Fig. 4

Impact of Gagp6 S40A/Pol p6*-PR F56C mutation on IDV susceptibility. 293T cells were co-transfected with DNA encoding the indicated construct and a plasmid encoding VSV G protein as described in “Methods”. IDV was present at 0 (a) or 0.01 μM (b). Viral supernatants were collected at 48 h post-transfection and serial dilutions were used in triplicate to infect 1 × 104 TZM-bl cells in 96-well plates. Infectivity of the virus particles in TZM-bl cells was assessed at 48 h post-infection using the reporter β-galactosidase

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