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Table 4 Association of V1 loop length and its glycan content with sensitivity of Env-pseudotyped viruses to neutralizing mAbs

From: HIV-1 clade C escapes broadly neutralizing autologous antibodies with N332 glycan specificity by distinct mechanisms

Envelopes and Chimera

INDO-SA 2007 BCN plasma (ID50 values)

IC50 (µg/ml)

b12

VRC01

PG9

PG16

PGT121

PGT128

HIV-1 NLR 2007.J12

43

>10

>10

0.04

0.14

>10

>10

HIV-1 NLR 2007.J48

25

>10

>10

0.06

0.08

>10

>10

HIV-1 NLR 2007.J48 (S332N)

250

>10

>10

0.09

0.07

0.12

0.08

HIV-1 NLR 2007.J48 (V1) in HIV-1 NLR 2007.J12

208

>10

>10

0.22

<0.04

0.29

0.13

HIV-1 NLR 2007.J12 (V1) in HIV-1 NLR 2007.J48 (S332 N)

96

>10

>10

0.33

0.66

2.14

>10

HIV-1 NLR 2007.J12 (Δ V1 N-glycans)

84.88

>10

>10

0.09

2.56

0.46

0.27