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Table 1 Neutralization breadth of the INDO-SA 2007 BCN plasma antibodies

From: HIV-1 clade C escapes broadly neutralizing autologous antibodies with N332 glycan specificity by distinct mechanisms

Origin

Envs (n = 28)

Tier

GenBank Tier Accession No

ID50 values

V1 loop length

N332/N334

Negative virus controls

MuLV

 

DQ359272.1

<20

N/A

 

HIV-2 (7312A)

 

L36874

<20

N/A

 

India C (n = 9)

00836-2.5

2

EF117265

450

21

Absent

25711-2.4

1B

EF117272

2789

25

N332

26191-2.48

2

EF117274

500

16

N332

16055-2.3

2

EF117268

382

23

Absent

16936-2.21

2

EF117270

694

20

N332

4-2.J41

–

GU945316.2

705

19

N334

5-4.J16

–

GU945326.1

1233

21

N332

7-J.20

–

EU908223.1

1384

23

N332

11-5.J12

–

GU945332.1

2715

18

N334

South Africa C (n = 8)

Du151.2

2

DQ411851.1

249

17

N332

Du156.12

2

DQ411852.1

770

24

N332

Du172.17

2

DQ411853.1

1019

29

N332

Du422.1

2

DQ411854.1

246

26

N332

CAP45.G3

2

DQ435682.1

710

16

N334

CAP84.32

2

EF203963.1

1017

15

N332

CAP88.B5

2

EF203972.1

793

28

N332

CAP239.G3

2

EF203983.1

1090

17

N332

Others (n = 11)

JRFL

2

U63632.1

97

24

N332

JRCSF

2

M38429.1

1527

24

N332

PVO.4

3

AY835444.1

553

29

N332

SC422661.8

2

AY835441.1

744

23

N332

RHPA4259.7

2

AY835447.1

871

22

N332

92BR020

1

AY669718.1

1015

a

N332

92TH021

2

AY669775.1

322

28

N334

93IN905

2

AY669742.1

6896

15

N332

94UG103

2

AY669705.1

108

a

N332

191727_D1.12

–

HM215267.1

<50

30

–

IAVI C22

–

–

1940

–

–

 

Geometric Mean Titer

749

  
  1. aThe V1 loop sequence of 92BR020 and 94UG103are unavailable in the NCBI GenBank database. ID50 values refer to the reciprocal dilution that conferred 50 % neutralization of viruses in a TZM-bl assay. Assays were done in duplicates and were repeated more than three times