Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Mutation frequencies and reversion analysis of vif of F-MLV-Vif proviruses bearing different Vif variants in splenic DNA of infected APOBEC3 KO, A3Ghigh and A3Glow transgenic mice

From: The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model

  NL43 W11R K22E K22H Y40H G143R
KO A3GLow A3GHigh KO A3GLow A3GHigh KO A3GLow A3GHigh KO A3GLow A3GHigh KO A3GLow A3GHigh KO A3GLow A3GHigh
#G to A 0 2 4 2 1 6 1 14 19 1 10 22 0 5 12 2 2 3
#other 8 7 10 9 8 9 9 9 12 7 9 11 8 10 10 9 8 9
#clones 15 14 14 15 14 15 15 12 15 13 14 14 14 14 14 15 15 14
#bp 8700 8120 8120 8700 8120 8700 8700 6960 8700 7540 8120 8120 8120 8120 8120 8700 8700 8120
G to A freq. ×10−3 0.00 0.25 0.49 0.23 0.12 0.69 0.11 2.01 2.18 0.13 1.23 2.71 0.00 0.62 1.48 0.23 0.23 0.37
Other freq. ×10−3 0.92 0.86 1.23 1.03 0.99 1.03 1.03 1.29 1.38 0.93 1.11 1.35 0.99 1.23 1.23 1.03 0.92 1.11
#stop codons 0 0 1 0 1 3 1 4 3 2 5 8 0 1 3 1 1 3
#revertants NA NA NA 0/15 0/14 0/15 0/15 1/12 3/15 0/13 1/14 2/14 0/14 0/14 2/14 0/15 0/15 0/15
  1. Analysis was performed on DNA cloned from a single infected mouse in Fig. 2a. F-MLV has a total of 38 GG motifs in the 580 region that was sequenced