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Fig. 2 | Retrovirology

Fig. 2

From: The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model

Fig. 2

Relative virus titers in the spleens of A3G transgenic mice after infection of with F-MLV-Vif variants. a Newborn A3 knock-out or A3G transgenic mice were infected intraperitoneally with 104 PFU of the different F-MLV-Vif variants. Spleens were collected 16 days post infection and splenocytes were isolated for assessment of viral levels by infectivity assays on Mus dunni fibroblasts. b Newborn mice were also infected with 103 (left) or 104 (right) PFU of F-MLV-VifTF or F-MLV-VifK19N/Q136H. Each point represents the titer obtained from each individual mouse normalized to the average titer measured in the spleens of A3 KO mice infected with the same virus (A3G/KO). Each point represents the viral load measured from an individual mouse; the mean (horizontal bar) and standard deviation for each group is shown. The transgenic mice were derived from 2 to 4 litters each; the knockout mice are the littermates of the transgenic mice. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; NS not significant (Mann–Whitney T test)

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