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Table 1 Restriction activity of Fv1n and Fv1b against MLVs at different expression levels

From: Expression levels of Fv1: effects on retroviral restriction specificities

Vector TGx-Fv1 TGIx-Fv1 LxIG-Fv1
Dox (ng/mL) 0 1000 0 1000 0
Fv1n      
 N-MLV 1.15 ± 0.07 1.16 ± 0.04 1.22 ± 0.11 1.13 ± 0.05 1.07 ± 0.03
 B-MLV 1.15 ± 0.09 0.24 ± 0.04 0.56 ± 0.01 0.14 ± 0.02 0.06 ± 0.01
 NB-MLV 1.17 ± 0.06 1.18 ± 0.04 1.21 ± 0.04 1.09 ± 0.06 1.08 ± 0.01
Fv1b      
 N-MLV 1.02 ± 0.09 0.17 ± 0.01 0.45 ± 0.09 0.13 ± 0.01 0.07 ± 0.02
 B-MLV 1.13 ± 0.07 1.10 ± 0.06 1.12 ± 0.02 0.87 ± 0.01 0.63 ± 0.02
 NB-MLV 1.21 ± 0.04 0.79 ± 0.03 1.01 ± 0.07 0.35 ± 0.02 0.21 ± 0.03
  1. Table shows mean and standard deviation values calculated from three independent restriction experiments carried out in transduced MDTF-R18 cells. A lower restriction ratio indicates stronger inhibition by Fv1. We arbitrarily divide restriction activity into three levels; Full, shown in bolditalic (restriction ratio ≤0.3), Partial, indicated in italics (0.3 < ratio ≤ 0.7) and None (ratio > 0.7)