Table 1 Summary Vif-mediated A3 degradation
From: Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors
Feline A3a | Degradation by Vif | Rescue of infection by Vifb | |||||
|---|---|---|---|---|---|---|---|
FIV | HIV-1 | HIV-2 | SIVmac/smm | FIV | HIV-2 | SIVmac | |
A3Z2 | ++ | − | − | − | ND | − | − |
A3Z2.DH-YN | − | ND | ND | ND | ND | ND | ND |
A3Z3 | ++ | − | − | − | ++ | − | − |
A3Z3.A65I | ± | ND | ND | ND | ± | ND | ND |
A3Z3.LI-AA | ± | ND | ND | ND | ± | ND | ND |
A3Z3.A65I + LI-AA | − | ND | ND | ND | − | ND | ND |
A3Z2Z3 | ++ | − | ++ | ++ | ++ | ++ | ++ |
A3Z2Z3-M | − | ND | ++ | ++ | − | ND | ND |
A3Z2Z3ΔLinker | ++ | − | ± | ± | ND | ND | ND |