Association of mutations in V3/C3 domain with enhanced sensitivity of HIV-1 clade C primary envelopes to autologous broadly neutralizing plasma antibodies

Table 1 Similarity of amino acid sequence of PG80 v2.eJ7 env with that of other autologous envs

Donor visit #	Autologous envs	% Identity^a	% Similarity^b
Visit # 2	PG80v2.eJ7	100.0	100.0
	PG80v2.eJ38	95.7	98.0
	PG80v2.eJ41	95.3	98.0
Visit # 1	PG80v1.eJ6a	94.0	97.2
	PG80v1.eJ7	94.3	97.6
	PG80v1.eJ19	92.9	97.3
	PG80v1.eJ158	93.2	97.2
	PG80v1.eJ166	93.8	97.4

LALIGN tool (http://www.ch.embnet.org/software/LALIGN_form.html) was used to obtain sequence identity and similarity
^a‘% identity’ refers to the degree of correlation between two un-gapped sequences and indicates that the amino acid at the particular position is an exact match
^b‘ % similarity’ refers to the degree of resemblance between two sequences and indicates that the amino acids at a particular position have some properties in common (e.g., charge or hydrophobicity) but are not identical

ISSN: 1742-4690