Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility

Lassaunière, Ria; Musekiwa, Alfred; Gray, Glenda E.; Kuhn, Louise; Tiemessen, Caroline T.

doi:10.1186/s12977-016-0272-y

Table 6 Multivariate analysis adjusted FcγRIIIa-F158V

From: Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility

	Multivariate, not adjusted for FcγRIIIa-F158V	P_Bonf	Multivariate analysis with adjustment for FcγRIIIa-F158V genotype and allele carriage
	Multivariate, not adjusted for FcγRIIIa-F158V	P_Bonf	F158V genotype	P_Bonf	≥1 158F allele	P_Bonf	≥1 158V allele	P_Bonf
*Maternal*
FcγRIIa (rs1801274)
131RR genotype
Total transmitting	P = 0.023	ns	1.93 (0.82–4.57), P = 0.133	ns	2.25 (0.97–5.24), P = 0.133	ns	2.08 (0.89–4.86), P = 0.091	ns
In utero transmitting	P = 0.029	ns	9.37 (1.01–87.22), P = 0.049	ns	9.59 (1.05–87.37), P = 0.045	ns	10.26 (1.12–94.28), P = 0.040	ns
In utero-enriched transmitting	P = 0.048	ns	1.94 (0.66–5.70), P = 0.226	ns	2.60 (0.90–7.52), P = 0.077	ns	1.98 (0.67–5.80), P = 0.214	ns
≥1 131H allele
In utero transmitting	P = 0.045	ns	0.42 (0.14–1.29), P = 0.132	ns	0.40 (0.14–1.15), P = 0.088	ns	0.39 (0.13–1.18), P = 0.096	ns
≥1 131R allele
Total transmitting	P = 0.049	ns	1.80 (0.84–3.85), P = 0.128	ns	1.90 (0.89–4.05), P = 0.095	ns	1.91 (0.90–4.06), P = 0.091	ns
FcγRIIb (rs1050501)
232TT genotype
Total transmitting	P = 0.030	ns	2.06 (0.78–5.41), P = 0.144	ns	2.48 (0.96–9.36), P = 0.060	ns	2.17 (0.83–5.67), P = 0.115	ns
≥1 232I allele
Total transmitting	P = 0.043	ns	0.49 (0.20–1.20), P = 0.118	ns	0.43 (0.18–1.05), P = 0.063	ns	0.48 (0.20–1.18), P = 0.110	ns
FcγRIIIb
≥1 HNA1b allotype
Total transmitting	P = 0.014	ns	2.26 (1.22–4.17), P = 0.009	ns	2.19 (1.20–4.02), P = 0.011	ns	2.21 (1.20–4.11), P = 0.011	ns
In utero-enriched transmitting	P = 0.031	ns	2.43 (1.15–5.16), P = 0.020	ns	2.32 (1.11–4.82), P = 0.025	ns	2.40 (1.13–5.10), P = 0.023	ns
*Infant*
FcγRIIIb
HNA1a+/1b−/1c− genotype
Total infected	P = 0.033	ns	0.37 (0.15–0.93), P = 0.034	ns	0.37 (0.15–0.91), P = 0.031	ns	0.37 (0.15–0.93), P = 0.034	ns
Intrapartum infected	P = 0.044	ns	0.20 (0.04–0.96), P = 0.044	ns	0.19 (0.04–0.95), P = 0.043	ns	0.20 (0.04–0.96), P = 0.044	ns
HNA1a+/1b+/1c+ genotype
In utero-enriched infected	P = 0.032	ns	5.67 (1.39–23.11), P = 0.016	ns	4.47 (1.13–17.64), P = 0.032	ns	5.74 (1.39–23.57), P = 0.015	ns
≥1 HNA1b allotype
Total infected	P = 0.019	ns	2.11 (1.16–3.83), P = 0.014	ns	2.04 (1.12–3.69), P = 0.019	ns	2.08 (1.15–3.77), P = 0.016	ns
In utero-enriched infected	P = 0.037	ns	2.29 (1.10–4.76), P = 0.026	ns	2.22 (1.07–4.58), P = 0.032	ns	2.26 (1.09–4.68), P = 0.028	ns

P values less than 0.05 are indicated in italics
P _Bonf Bonferroni corrected P value, AOR adjusted odds ratio, CI confidence interval, VL viral load, bwt birth weight, ns not statistically significant
–, the variable of interest was not detected in any of the cases and thus could not be analysed

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ISSN: 1742-4690

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