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Table 5 Infant FcγR variants associated with perinatal HIV-1 acquisition after adjusting for confounding variables

From: Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility

 

Total infected

Intrapartum infected

Univariate

Adjusted for VLa

PBonf

Univariate

Adjusted for VL

PBonf

AOR (95 % CI)

P value

AOR (95 % CI)

P value

FcγRIIa (rs1801274)

        

Genotype

        

 131HH (ref)

 

1

   

1

  

 131HR

P = 0.426

0.79 (0.38–1.62)

P = 0.519

ns

P = 0.670

0.80 (0.27–2.32)

P = 0.685

ns

 131RR

P = 0.516

0.84 (0.39–1.83)

P = 0.657

ns

P = 0.895

0.97 (0.31–2.97)

P = 0.951

ns

Allele carriage

        

 ≥1 131H allele

P = 0.848

1.01 (0.55–1.85)

P = 0.970

ns

P = 0.854

0.89 (0.37–2.12)

P = 0.792

ns

 ≥1 131R allele

P = 0.414

0.81 (0.41–1.59)

P = 0.536

ns

P = 0.737

0.87 (0.32–2.32)

P = 0.774

ns

FcγRIIb (rs1050501)

        

Genotype

        

 232II (ref)

 

1

   

1

  

 232IT

P = 0.583

1.29 (0.70–2.39)

P = 0.415

ns

P = 0.811

1.40 (0.57–3.44)

P = 0.469

ns

 232TT

P = 0.110

1.97 (0.89–4.37)

P = 0.096

ns

P = 0.525

1.82 (0.56–5.90)

P = 0.317

ns

Allele carriage

        

 ≥1 232I allele

P = 0.132

0.57 (0.28–1.20)

P = 0.140

ns

P = 0.554

0.65 (0.22–1.90)

P = 0.429

ns

 ≥1 232T allele

P = 0.280

1.46 (0.83–2.57)

P = 0.195

ns

P = 0.660

1.50 (0.65–3.47)

P = 0.344

ns

FcγRIIIa (rs396991)

        

Genotype

        

 158F/FF/FF (ref)

 

1

   

1

  

 158FV/FFV/FVV

P = 0.456

0.87 (0.49–1.56)

P = 0.647

ns

P = 0.821

1.14 (0.49–2.66)

P = 0.764

ns

 158V/VV

P = 0.145

0.28 (0.08–1.00)

P = 0.051

ns

P = 0.899

0.28 (0.03–2.27)

P = 0.232

ns

Allele carriage

        

 ≥1 158F allele

P = 0.272

3.34 (0.96–11.57)

P = 0.058

ns

P = 0.819

3.89 (0.50–30.31)

P = 0.194

ns

 ≥1 158V allele

P = 0.198

0.75 (0.43–1.31)

P = 0.311

ns

P = 0.964

0.95 (0.42–2.19)

P = 0.910

ns

FcγRIIIb

        

Genotype

        

 HNA1a+/1b−/1c−

P = 0.040

0.37 (0.15–0.92)

P = 0.033

ns

P = 0.035

0.20 (0.04–0.96)

P = 0.044

ns

 HNA1a−/1b+/1c−

P = 0.565

0.69 (0.25–1.86)

P = 0.459

ns

P = 0.160

0.20 (0.03–1.69)

P = 0.139

ns

 HNA1a−/1b−/1c+

P = 0.672

0.70 (0.18–2.78)

P = 0.616

ns

–

–

 

P = 0.970

 HNA1a+/1b+/1c− (ref)

 

1

   

1

  

 HNA1a+/1b−/1c+

P = 0.643

0.73 (0.31–1.72)

P = 0.478

ns

P = 0.863

0.97 (0.33–2.79)

P = 0.949

ns

 HNA1a−/1b+/1c+

P = 0.260

1.57 (0.64–3.88)

P = 0.326

ns

P = 0.272

1.80 (0.57–5.71)

P = 0.316

ns

 HNA1a+/1b+/1c+

P = 0.086

2.36 (0.63–8.75)

P = 0.201

ns

P = 0.843

–

ns

P = 0.123

Allele carriage

        

 ≥1 HNA1a allotype

P = 0.408

0.79 (0.43–1.46)

P = 0.452

ns

P = 0.986

1.01 (0.40–2.56)

P = 0.981

ns

 ≥1 HNA1b allotype

P = 0.020

2.02 (1.12–3.64)

P = 0.019

ns

P = 0.079

1.91 (0.81–4.53)

P = 0.140

ns

 ≥1 HNA1c allotype

P = 0.075

1.52 (0.86–2.69)

P = 0.146

ns

P = 0.110

1.74 (0.77–3.96)

P = 0.185

ns

 

In utero infected

In utero-enriched infected

 

Univariate

Adjusted for VL + bwt

PBonf

Univariate

Adjusted for VL

PBonf

AOR (95 % CI)

P value

AOR (95 % CI)

P value

FcγRIIa (rs1801274)

        

Genotype

        

 131HH (ref)

 

1

   

1

  

 131HR

P = 0.456

0.71 (0.15–3.25)

P = 0.657

ns

P = 0.455

0.75 (0.32–1.79)

P = 0.520

ns

 131RR

P = 0.541

1.87 (0.45–7.79)

P = 0.390

ns

P = 0.433

0.77 (0.30–1.96)

P = 0.581

ns

Allele carriage

        

 ≥1 131H allele

P = 0.139

0.42 (0.15–1.21)

P = 0.108

ns

P = 0.685

1.07 (0.51–2.22)

P = 0.858

ns

 ≥1 131R allele

P = 0.912

1.17 (0.31–4.58)

P = 0.817

ns

P = 0.396

0.76 (0.34–1.70)

P = 0.503

ns

FcγRIIb (rs1050501)

        

Genotype

        

 232II (ref)

 

1

   

1

  

 232IT

P = 0.862

0.80 (0.23–2.74)

P = 0.724

ns

P = 0.577

1.18 (0.56–2.50)

P = 0.658

ns

 232TT

P = 0.038

3.53 (0.95–13.14)

P = 0.060

ns

P = 0.092

2.02 (079–5.16)

P = 0.144

ns

Allele carriage

        

 ≥1 232I allele

P = 0.026

0.26 (0.08–0.86)

P = 0.028

ns

P = 0.110

0.54 (0.23–1.28)

P = 0.160

ns

 ≥1 232T allele

P = 0.298

1.33 (0.47–3.77)

P = 0.593

ns

P = 0.264

1.38 (0.70–2.74)

P = 0.353

ns

FcγRIIIa (rs396991)

        

Genotype

        

 158F/FF/FF (ref)

 

1

   

1

  

 158FV/FFV/FVV

P = 0.391

0.61 (0.20–1.86)

P = 0.385

ns

P = 0.410

0.74 (0.37–1.49)

P = 0.405

ns

 158V/VV

P = 0.550

0.85 (0.16–4.42)

P = 0.842

ns

P = 0.073

0.29 (0.06–1.36)

P = 0.117

ns

Allele carriage

        

 ≥1 158F allele

P = 0.354

0.93 (0.19–4.53)

P = 0.931

ns

P = 0.190

2.91 (0.66–12.92)

P = 0.160

ns

 ≥1 158V allele

P = 0.740

0.66 (0.23–1.85)

P = 0.425

ns

P = 0.100

0.65 (0.33–1.28)

P = 0.215

ns

FcγRIIIb

        

Genotype

        

 HNA1a+/1b−/1c−

P = 0.709

0.77 (0.15–3.86)

P = 0.748

ns

P = 0.350

0.53 (0.18–1.52)

P = 0.234

ns

 HNA1a−/1b+/1c−

P = 0.631

0.46 (0.04–4.76)

P = 0.513

ns

P = 0.678

1.13 (0.37–3.42)

P = 0.827

ns

 HNA1a−/1b−/1c+

P = 0.970

1.48 (0.14–15.83)

P = 0.744

ns

P = 0.532

1.33 (0.32–5.54)

P = 0.695

ns

 HNA1a+/1b+/1c− (ref)

 

1

   

1

  

 HNA1a+/1b−/1c+

P = 0.808

0.65 (0.10–4.10)

P = 0.645

ns

P = 0.365

0.50 (0.15–1.67)

P = 0.259

ns

 HNA1a−/1b+/1c+

P = 0.077

4.47 (0.84–23.80)

P = 0.080

ns

P = 0.518

1.50 (0.46–4.92)

P = 0.501

ns

 HNA1a+/1b+/1c+

P = 0.123

3.35 (0.40–27.73)

P = 0.262

ns

P = 0.017

4.44 (1.14–17.40)

P = 0.032

ns

Allele carriage

        

 ≥1 HNA1a allotype

P = 0.307

0.58 (0.19–1.76)

P = 0.337

ns

P = 0.258

0.66 (0.32–1.37)

P = 0.265

ns

 ≥1 HNA1b allotype

P = 0.231

1.82 (0.63–5.32)

P = 0.271

ns

P = 0.079

2.16 (1.05–4.44)

P = 0.037

ns

 ≥1 HNA1c allotype

P = 0.101

2.16 (0.76–6.14)

P = 0.149

ns

P = 0.243

1.42 (0.71–2.81)

P = 0.321

ns

  1. P values less than 0.05 are indicated in italics
  2. P Bonf Bonferroni corrected P value, AOR adjusted odds ratio, CI confidence interval, VL viral load, bwt birth weight, –, the variable of interest was not detected in any of the cases and thus could not be analysed
  3. aThe multivariate analysis adjusted for demographic and clinical variables that independently associated with transmission. Due to high correlation with viral load, CD4 T cell counts were not included in the multivariate model
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