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Table 4 FcγR genotypes and allele carriage in HIV-1 exposed-uninfected and infected infants

From: Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility

 

Exposed-uninfected

Total infected

Intrapartum infected

N (%)

N (%)

OR (95 % CI)

P value

PBonf

N (%)

OR (95 % CI)

P value

PBonf

FcγRIIa (rs1801274)

Overall association

 

P = 0.704

ns

  

P = 0.907

ns

Genotype

         

 131HH (ref)

47 (20.0)

19 (24.4)

1

  

7 (22.6)

1

  

 131HR

116 (49.4)

36 (46.2)

0.77 (0.40–1.47)

P = 0.426

ns

14 (45.2)

0.81 (0.31–2.13)

P = 0.670

ns

 131RR

72 (30.6)

23 (29.5)

0.79 (0.39–1.61)

P = 0.516

ns

10 (32.3)

0.93 (0.33–2.62)

P = 0.895

ns

Allele carriage

         

 ≥1 131H allele

163 (69.4)

55 (70.5)

1.06 (0.60–1.85)

P = 0.848

ns

21 (67.7)

0.93 (0.42–2.07)

P = 0.854

ns

 ≥1 131R allele

188 (80.0)

59 (75.6)

0.76 (0.42–1.43)

P = 0.414

ns

24 (77.4)

0.86 (0.35–2.11)

P = 0.737

ns

FcγRIIb (rs1050501)

Overall association

 

P = 0.278

ns

  

P = 0.773

ns

Genotype

         

 232II (ref)

116 (49.4)

33 (42.3)

1

  

14 (45.2)

1

  

 232IT

90 (38.3)

30 (38.5)

1.17 (0.67–2.06)

P = 0.583

ns

12 (38.7)

1.10 (0.49–2.51)

P = 0.811

ns

 232TT

29 (12.3)

15 (19.2)

1.82 (0.87–3.79)

P = 0.110

ns

5 (16.1)

1.43 (0.48–4.29)

P = 0.525

ns

Allele carriage

         

 ≥1 232I allele

206 (86.8)

63 (78.6)

0.59 (0.30–1.17)

P = 0.132

ns

26 (83.9)

0.73 (0.26–2.06)

P = 0.554

ns

 ≥1 232T allele

119 (47.2)

45 (55.7)

1.33 (0.79–2.23)

P = 0.280

ns

17 (54.8)

1.18 (0.56–2.51)

P = 0.660

ns

FcγRIIIa (rs396991)

Overall association

P = 0.339

 

ns

  

P = 0.964

ns

Genotype

         

 158F/FF/FF (ref)

86 (36.6)

34 (43.6)

1

  

12 (38.7)

1

  

 158FV/FFV/FVV

118 (50.2)

38 (48.7)

0.81 (0.47–1.40)

P = 0.456

ns

15 (48.4)

0.91 (0.41–2.04)

P = 0.821

ns

 158V/VV

31 (13.2)

6 (7.7)

0.49 (0.19–1.28)

P = 0.145

ns

4 (12.9)

0.92 (0.28–3.08)

P = 0.899

ns

Allele carriage

         

 ≥1 158F allele

194 (82.6)

72 (92.3)

0.75 (0.44–1.26)

P = 0.272

ns

27 (87.1)

0.91 (0.42–1.97)

P = 0.819

ns

 ≥1 158V allele

149 (63.4)

44 (56.4)

1.82 (0.73–4.55)

P = 0.198

ns

19 (61.3)

1.03(0.34–3.13)

P = 0.964

ns

FcγRIIIb

Overall association

 

P = 0.046

ns

  

P = 0.023

ns

Genotype

         

 HNA1a+/1b−/1c−

58 (24.7)

9 (11.5)

0.42 (0.18–0.96)

P = 0.040

ns

2 (6.5)

0.19(0.04–0.89)

P = 0.035

ns

 HNA1a−/1b+/1c−

25 (10.6)

7 (9.0)

0.76 (0.29–1.95)

P = 0.565

ns

1 (3.2)

0.22 (0.03–1.81)

P = 0.160

ns

 HNA1a−/1b−/1c+

14 (6.0)

4 (5.1)

0.77 (0.23–2.55)

P = 0.672

ns

0 (0)

–

  

 HNA1a+/1b+/1c− (ref)

73 (31.2)

27 (34.6)

1

  

13 (41.9)

1

  

 HNA1a+/1b−/1c+

36 (15.3)

11 (14.1)

0.83 (0.37–1.85)

P = 0.643

ns

7 (22.6)

1.09 (0.40–2.97)

P = 0.863

ns

 HNA1a−/1b+/1c+

22 (9.4)

13 (16.7)

1.60 (0.71–3.61)

P = 0.260

ns

7 (22.6)

1.79 (0.63–5.03)

P = 0.272

ns

 HNA1a+/1b+/1c+

7 (3.0)

7 (9.0)

2.70 (0.87–8.43)

P = 0.086

ns

1 (3.2)

0.80 (0.09–7.07)

P = 0.843

ns

Allele carriage

         

 ≥1 HNA1a allotype

174 (74.0)

54 (69.2)

0.79 (0.45–1.38)

P = 0.408

ns

23 (74.2)

1.01 (0.43–2.37)

P = 0.986

ns

 ≥1 HNA1b allotype

127 (54.0)

54 (69.2)

1.91 (1.11–3.30)

P = 0.020

ns

22 (71.0)

2.08 (0.92–4.70)

P = 0.079

ns

 ≥1 HNA1c allotype

79 (33.6)

35 (44.9)

1.61 (0.95–2.71)

P = 0.075

ns

15 (48.4)

1.85 (0.87–3.94)

P = 0.110

ns

 

In utero infected

In utero-enriched infected

N (%)

OR (95 % CI)

P value

PBonf

N (%)

OR (95 % CI)

P value

PBonf

FcγRIIa (rs1801274)

  

P = 0.265

ns

  

P = 0.693

ns

Genotype

        

 131HH (ref)

4 (21.1)

1

  

12 (25.5)

1

  

 131HR

6 (31.6)

0.61 (0.16–2.25)

P = 0.456

ns

22 (46.8)

0.74 (0.34–1.62)

P = 0.455

ns

 131RR

9 (47.4)

1.47 (0.43–5.04)

P = 0.541

ns

13 (27.7)

0.71 (0.30–1.68)

P = 0.433

ns

Allele carriage

        

 ≥1 131H allele

10 (52.6)

0.49 (0.19–1.26)

P = 0.139

ns

34 (72.3)

1.16 (0.58–2.32)

P = 0.685

ns

 ≥1 131R allele

15 (78.9)

0.94 (0.30–2.96)

P = 0.912

ns

35 (74.5)

0.73 (0.35–1.51)

P = 0.396

ns

FcγRIIb (rs1050501)

  

P = 0.083

ns

  

P = 0.218

ns

Genotype

        

 232II (ref)

7 (36.8)

1

  

19 (40.4)

1

  

 232IT

6 (31.6)

1.10 (0.36–3.40)

P = 0.862

ns

18 (38.3)

1.22 (0.61–2.46)

P = 0.577

ns

 232TT

6 (31.6)

3.43 (1.07–10.98)

P = 0.038

ns

10 (21.3)

2.11 (0.88–5.01)

P = 0.092

ns

Allele carriage

        

 ≥1 232I allele

13 (68.4)

0.31 (0.11–0.87)

P = 0.026

ns

37 (78.7)

0.52 (0.23–1.16)

P = 0.110

ns

 ≥1 232T allele

12 (63.2)

1.67 (0.64–4.39)

P = 0.298

ns

28 (59.6)

1.44 (0.76–2.71)

P = 0.264

ns

FcγRIIIa (rs396991)

  

P = 0.711

ns

  

P = 0.145

ns

Genotype

        

 158F/FF/FF (ref)

9 (47.4)

1

  

22 (46.8)

1

  

 158FV/FFV/FVV

8 (42.1)

0.65 (0.24–1.75)

P = 0.391

ns

23 (48.9)

0.76 (0.40–1.46)

P = 0.410

ns

 158V/VV

2 (10.5)

0.62 (0.13–3.01)

P = 0.550

ns

2 (4.3)

0.25 (0.06–1.14)

P = 0.073

ns

Allele carriage

        

 ≥1 158F allele

17 (89.5)

0.64 (0.25–1.64)

P = 0.354

ns

45 (95.7)

0.66 (0.35–1.23)

P = 0.190

ns

 ≥1 158V allele

10 (52.6)

1.29 (0.28–5.87)

P = 0.740

ns

25 (53.2)

3.42 (0.79–14.81)

P = 0.100

ns

FcγRIIIb

  

P = 0.182

ns

  

P = 0.079

ns

Genotype

        

 HNA1a+/1b−/1c−

3 (15.8)

0.76 (0.17–3.29)

P = 0.709

ns

7 (14.9)

0.63 (0.24–1.66)

P = 0.350

ns

 HNA1a−/1b+/1c−

1 (5.3)

0.58 (0.07–5.24)

P = 0.631

ns

6 (12.8)

1.25 (0.43–3.61)

P = 0.678

ns

 HNA1a−/1b−/1c+

1 (5.3)

1.04 (0.11–9.62)

P = 0.970

ns

4 (8.5)

1.49 (0.43–5.20)

P = 0.532

ns

 HNA1a+/1b+/1c− (ref)

5 (26.3)

1

  

14 (29.8)

1

  

 HNA1a+/1b−/1c+

2 (10.5)

0.81 (0.15–4.39)

P = 0.808

ns

4 (8.5)

0.58 (0.18–1.89)

P = 0.365

ns

 HNA1a−/1b+/1c+

5 (26.3)

3.32 (0.88–12.52)

P = 0.077

ns

6 (12.8)

1.42 (0.49–4.14)

P = 0.518

ns

 HNA1a+/1b+/1c+

2 (10.5)

4.17 (0.68–25.59)

P = 0.123

ns

6 (12.8)

4.47 (1.30–15.31)

P = 0.017

ns

Allele carriage

        

 ≥1 HNA1a allotype

12 (63.2)

0.60 (0.23–1.60)

P = 0.307

ns

31 (66.0)

0.70 (0.35–1.33)

P = 0.258

ns

 ≥1 HNA1b allotype

13 (68.4)

1.84 (0.68–5.01)

P = 0.231

ns

32 (68.1)

1.81 (0.93–3.53)

P = 0.079

ns

 ≥1 HNA1c allotype

10 (52.6)

2.19 (0.86–5.62)

P = 0.101

ns

20 (42.6)

1.46 (0.77–2.77)

P = 0.243

ns

  1. P values less than 0.05 are indicated in italics
  2. P Bonf Bonferroni corrected P value, OR odds ratio, CI confidence interval, ns not statistically significant, –, the variable of interest was not detected in any of the cases and thus could not be analysed
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