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Table 3 Maternal FcγR variants associated with perinatal HIV-1 transmission after adjusting for confounding variables

From: Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility

 

Total transmitting

Intrapartum transmitting

Univariate

Adjusted for VLa

PBonf

Univariate

Adjusted for VL

PBonf

AOR (95 % CI)

P value

AOR (95 % CI)

P value

FcγRIIa (rs1801274)

        

Genotype

        

 131HH (ref)

 

1

   

1

  

 131HR

P = 0.378

1.81 (0.82–3.99)

P = 0.141

ns

P = 0.558

1.43 (0.46–4.46)

P = 0.539

ns

 131RR

P = 0.172

2.59 (1.14–5.87)

P = 0.023

ns

P = 0.371

2.57 (0.80–8.26)

P = 0.113

ns

Allele carriage

        

 ≥1 131H allele

P = 0.288

0.58 (0.33–1.05)

P = 0.071

ns

P = 0.464

0.49 (0.21–1.16)

P = 0.106

ns

 ≥1 131R allele

P = 0.233

2.11 (1.00–4.42)

P = 0.049

ns

P = 0.449

1.82 (0.64–5.23)

P = 0.263

ns

FcγRIIb (rs1050501)

        

Genotype

        

 232II (ref)

 

1

   

1

  

 232IT

P = 0.450

1.29 (0.71–2.35)

P = 0.408

ns

P = 0.442

1.60 (0.65–3.93)

P = 0.309

ns

 232TT

P = 0.075

2.80 (1.11–7.10)

P = 0.030

ns

P = 0.242

3.25 (0.87–12.17)

P = 0.080

ns

Allele carriage

        

 ≥1 232I allele

P = 0.103

0.41 (0.17–0.97)

P = 0.043

ns

P = 0.239

0.40 (0.12–1.33)

P = 0.133

ns

 ≥1 232T allele

P = 0.231

1.49 (0.84–2.62)

P = 0.171

ns

P = 0.317

1.81 (0.77–4.28)

P = 0.175

ns

FcγRIIIa (rs396991)

        

Genotype

        

 158F/FF/FF (ref)

 

1

   

1

  

 158FV/FFV/FVV

P = 0.010

0.51 (0.28–0.92)

P = 0.026

ns

P = 0.672

1.09 (0.45–2.64)

P = 0.850

ns

 158V/VV

P = 0.041

0.30 (0.11–082)

P = 0.018

ns

P = 0.266

0.20 (0.02–1.70)

P = 0.141

ns

Allele carriage

        

 ≥1 158F allele

P = 0.217

2.29 (0.89–5.88)

P = 0.084

ns

P = 0.183

5.22 (0.67–40.41)

P = 0.114

ns

 ≥1 158V allele

P = 0.004

0.46 (0.26–0.82)

P = 0.008

ns

P = 0.980

0.89 (0.37–2.12)

P = 0.786

ns

FcγRIIIb

        

Genotype

        

 HNA1a+/1b−/1c−

P = 0.315

0.47 (0.20–1.10)

P = 0.083

ns

P = 0.276

0.45 (0.12–1.61)

P = 0.218

ns

 HNA1a−/1b+/1c−

P = 0.668

0.90 (0.33–2.46)

P = 0.839

ns

P = 0.837

1.31 (0.35–4.87)

P = 0.683

ns

 HNA1a−/1b−/1c+

–

–

  

–

–

  

 HNA1a+/1b+/1c− (ref)

 

1

   

1

  

 HNA1a+/1b−/1c+

P = 0.448

0.63 (0.26–1.51)

P = 0.300

ns

P = 0.727

0.68 (0.19–2.42)

P = 0.547

ns

 HNA1a−/1b+/1c+

P = 0.066

1.37 (0.59–3.19)

P = 0.466

ns

P = 0.502

1.20 (0.35–4.15)

P = 0.777

ns

 HNA1a+/1b+/1c+

P = 0.849

0.42 (0.10–1.71)

P = 0.226

ns

P = 0.916

0.42 (0.05–3.72)

P = 0.433

ns

Allele carriage

        

 ≥1 HNA1a allotype

P = 0.369

0.78 (0.43–1.44)

P = 0.433

ns

P = 0.648

0.73 (0.30–1.75)

P = 0.481

ns

 ≥1 HNA1b allotype

P = 0.025

2.11 (1.16–3.85)

P = 0.014

ns

P = 0.099

2.18 (0.90–5.33)

P = 0.086

ns

 ≥1 HNA1c allotype

P = 0.599

0.95 (0.54–1.68)

P = 0.865

ns

P = 0.869

0.88 (0.38–2.04)

P = 0.759

ns

 

In utero transmitting

In utero-enriched transmitting

Univariate

Adjusted for VL + bwt

PBonf

Univariate

Adjusted for VL

PBonf

AOR (95 % CI)

P value

AOR (95 % CI)

P value

FcγRIIa (rs1801274)

        

Genotype

        

 131HH (ref)

 

1

   

1

  

 131HR

P = 0.241

5.74 (0.66–49.93)

P = 0.113

ns

P = 0.447

2.28 (0.84–6.17)

P = 0.105

ns

 131RR

P = 0.085

11.46 (1.29–101.86)

P = 0.029

ns

P = 0.225

2.82 (1.01–7.89)

P = 0.048

ns

Allele carriage

        

 ≥1 131H allele

P = 0.143

0.34 (0.12–0.97)

P = 0.045

ns

P = 0.383

0.63 (0.32–1.27)

P = 0.200

ns

 ≥1 131R allele

P = 0.136

7.65 (0.94–62.32)

P = 0.057

ns

P = 0.314

2.50 (0.97–6.40)

P = 0.057

ns

FcγRIIb (rs1050501)

        

Genotype

        

 232II (ref)

     

1

  

 232IT

P = 0.434

0.67 (0.22–2.06)

P = 0.487

ns

P = 0.678

1.15 (0.56–2.35)

P = 0.707

ns

 232TT

P = 0.153

3.38 (0.73–15.61)

P = 0.119

ns

P = 0.121

2.57 (0.85–7.74)

P = 0.094

ns

Allele carriage

        

 ≥1 232I allele

P = 0.072

0.25 (0.06–1.07)

P = 0.062

ns

P = 0.133

0.42 (0.15–1.18)

P = 0.100

ns

 ≥1 232T allele

P = 0.883

0.93 (0.34–2.54)

P = 0.891

ns

P = 0.403

1.33 (0.67–2.61)

P = 0.412

ns

FcγRIIIa (rs396991)

        

Genotype

        

 158F/FF/FF (ref)

 

1

   

1

  

 158FV/FFV/FVV

P = 0.108

0.60 (0.21–1.71)

P = 0.341

ns

P = 0.0001

0.29 (0.14–0.63)

P = 0.002

ns

 158V/VV

P = 0.115

0.19 (0.02–1.68)

P = 0.135

ns

P = 0.069

0.34 (0.11–0.98)

P = 0.046

ns

Allele carriage

        

 ≥1 158F allele

P = 0.222

4.01 (0.48–33.16)

P = 0.198

ns

P = 0.562

1.71 (0.61–4.80)

P = 0.305

ns

 ≥1 158V allele

P = 0.048

0.50 (0.18–1.36)

P = 0.174

ns

P = 0.0001

0.31 (0.15–0.62)

P = 0.001

0.042

FcγRIIIb

        

Genotype

        

 HNA1a+/1b−/1c−

P = 0.155

1.44 (0.30–6.85)

P = 0.644

ns

P = 0.612

0.45 (0.16–1.24)

P = 0.124

ns

 HNA1a−/1b+/1c−

P = 0.971

1.26 (0.12–13.63)

P = 0.851

ns

P = 0.429

0.66 (0.17–2.56)

P = 0.544

ns

 HNA1a−/1b−/1c+

–

–

  

–

–

  

 HNA1a+/1b+/1c− (ref)

 

1

   

1

  

 HNA1a+/1b−/1c+

P = 0.267

1.88 (0.37–9.46)

P = 0.442

ns

P = 0.448

0.59 (0.20–1.68)

P = 0.321

ns

 HNA1a−/1b+/1c+

P = 0.028

3.10 (0.60–15.95)

P = 0.177

ns

P = 0.047

1.53 (0.58–4.02)

P = 0.388

ns

 HNA1a+/1b+/1c+

P = 0.562

1.10 (0.10–12.45)

P = 0.939

ns

P = 0.723

0.44 (0.08–2.28)

P = 0.326

ns

Allele carriage

        

 ≥1 HNA1a allotype

P = 0.638

0.85 (0.28–2.63)

P = 0.783

ns

P = 0.388

0.79 (0.38–1.64)

P = 0.523

ns

 ≥1 HNA1b allotype

P = 0.659

1.09 (0.39–3.02)

P = 0.868

ns

P = 0.085

2.23 (1.08–4.62)

P = 0.031

ns

 ≥1 HNA1c allotype

P = 0.262

1.51 (0.55–4.14)

P = 0.420

ns

P = 0.560

1.04 (0.53–2.06)

P = 0.904

ns

  1. aThe multivariate analysis adjusted for demographic and clinical variables that independently associated with transmission. Due to high correlation with viral load, CD4 T cell counts were not included in the multivariate model
  2. P values less than 0.05 are indicated in italics
  3. P Bonf Bonferroni corrected P value, AOR adjusted odds ratio, CI confidence interval, VL viral load, bwt birth weight, ns not statistically significant, –, the variable of interest was not detected in any of the cases and thus could not be analysed
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