| Non-transmitting | Total transmitting | Intrapartum transmitting | ||||||
---|---|---|---|---|---|---|---|---|---|
N (%) | N (%) | OR (95Â % CI) | P value | PBonf | N (%) | OR (95Â % CI) | P value | PBonf | |
FcγRIIa (rs1801274) | Overall association |  | P = 0.379 | ns |  |  | P = 0.688 | ns | |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 131HH (ref) | 60 (25.6) | 15 (19.0) | 1 |  |  | 6 (19.4) | 1 |  |  |
 131HR | 106 (45.3) | 36 (45.6) | 1.36 (0.69–2.68) | P = 0.378 | ns | 14 (45.2) | 1.32 (0.48–3.62) | P = 0.558 | ns |
 131RR | 68 (29.1) | 28 (35.4) | 1.65 (0.80–3.37) | P = 0.172 | ns | 11 (35.5) | 1.62 (0.56–4.64) | P = 0.371 | ns |
Allele carriage | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 ≥1 131H allele | 166 (70.9) | 51 (64.6) | 0.75 (0.43–1.28) | P = 0.288 | ns | 20 (64.5) | 0.74 (0.34–1.64) | P = 0.464 | ns |
 ≥1 131R allele | 174 (74.4) | 64 (81.0) | 1.47 (0.78–2.77) | P = 0.233 | ns | 25 (80.6) | 1.44 (0.56–3.67) | P = 0.449 | ns |
FcγRIIb (rs1050501) | Overall association |  | P = 0.194 | ns |  |  | P = 0.397 | ns | |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 232II (ref) | 113 (48.3) | 32 (40.5) | 1 |  |  | 12 (38.7) | 1 |  |  |
 232IT | 103 (44.0) | 36 (45.6) | 1.23 (0.71–2.13) | P = 0.450 | ns | 15 (48.4) | 1.37 (0.61–3.07) | P = 0.442 | ns |
 232TT | 18 (7.7) | 11 (13.9) | 2.16 (0.93–5.03) | P = 0.075 | ns | 4 (12.9) | 2.09 (0.61–7.20) | P = 0.242 | ns |
Allele carriage | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 ≥1 232I allele | 216 (92.3) | 68 (86.3) | 0.52 (0.23–1.14) | P = 0.103 | ns | 27 (87.1) | 0.56 (0.18–1.79) | P = 0.239 | ns |
 ≥1 232T allele | 121 (51.7) | 47 (59.5) | 1.37 (0.82–2.30) | P = 0.231 | ns | 19 (61.3) | 1.48 (0.69–3.18) | P = 0.317 | ns |
FcγRIIIa (rs396991) | Overall association |  | P = 0.017 | ns |  |  | P = 0.380 | ns | |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 158F/FF/FF (ref) | 76 (32.5) | 40 (50.6) | 1 |  |  | 10 (32.3) | 1 |  |  |
 158FV/FFV/FVV | 121 (51.7) | 31 (39.2) | 0.49 (0.28–0.84) | P = 0.010 | ns | 19 (61.3) | 1.19 (0.53–2.70) | P = 0.672 | ns |
 158V/VV | 36 (15.4) | 8 (10.1) | 0.41 (0.17–0.97) | P = 0.041 | ns | 2 (6.5) | 0.41 (0.09–1.97) | P = 0.266 | ns |
Allele carriage | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 ≥1 158F allele | 197 (84.2) | 71 (89.9) | 1.67 (0.74–3.75) | P = 0.217 | ns | 29 (93.5) | 2.72 (0.62–11.91) | P = 0.183 | ns |
 ≥1 158V allele | 157 (67.1) | 39 (49.4) | 0.47(0.28–0.79) | P = 0.004 | ns | 21 (67.7) | 1.01 (0.45–2.25) | P = 0.980 | ns |
FcγRIIIb | Overall association |  | P = 0.058 | ns |  |  | P = 0.647 | ns | |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 HNA1a+/1b−/1c− | 51 (21.8) | 13 (16.5) | 0.68 (0.32–1.44) | P = 0.315 | ns | 4 (12.9) | 0.51 (0.15–1.70) | P = 0.276 | ns |
 HNA1a−/1b+/1c− | 23 (9.8) | 7 (8.9) | 0.81 (0.31–2.11) | P = 0.668 | ns | 4 (12.9) | 1.14 (0.33–3.92) | P = 0.837 | ns |
 HNA1a−/1b−/1c+ | 13 (5.6) | 0 (0) | – |  |  | 0 (0) | – |  |  |
 HNA1a+/1b+/1c− (ref) | 72 (30.8) | 27 (34.2) | 1 |  |  | 11 (35.5) | 1 |  |  |
 HNA1a+/1b−/1c+ | 40 (17.1) | 11 (13.9) | 0.73 (0.33–1.63) | P = 0.448 | ns | 5 (16.1) | 0.82 (0.27–2.52) | P = 0.727 | ns |
 HNA1a−/1b+/1c+ | 22 (9.4) | 17 (21.5) | 2.06 (0.95–4.46) | P = 0.066 | ns | 5 (16.1) | 1.49 (0.47–4.75) | P = 0.502 | ns |
 HNA1a+/1b+/1c+ | 12 (5.1) | 4 (5.1) | 0.89 (0.26–3.00) | P = 0.849 | ns | 2 (6.5) | 1.09 (0.21–5.54) | P = 0.916 | ns |
Allele carriage | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 ≥1 HNA1a allotype | 175 (74.8) | 55 (69.6) | 0.77 (0.44–1.36) | P = 0.369 | ns | 22 (71.0) | 0.82 (0.36–1.89) | P = 0.648 | ns |
 ≥1 HNA1b allotype | 129 (55.1) | 55 (69.6) | 1.87 (1.08–3.21) | P = 0.025 | ns | 22 (71.0) | 1.99 (0.88–4.50) | P = 0.099 | ns |
 ≥1 HNA1c allotype | 87 (37.2) | 32 (40.5) | 1.15 (0.68–1.94) | P = 0.599 | ns | 12 (38.7) | 1.07 (0.49–2.30) | P = 0.869 | ns |
 | In utero transmitting | In utero-enriched transmitting | ||||||
---|---|---|---|---|---|---|---|---|
 | N (%) | OR (95 % CI) | P value | PBonf | N (%) | OR (95 % CI) | P value | PBonf |
FcγRIIa (rs1801274) |  |  | P = 0.182 | ns |  |  | P = 0.545 | ns |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â |
 131HH (ref) | 2 (10.0) | 1 |  |  | 9 (18.8) | 1 |  |  |
 131HR | 9 (45.0) | 2.55 (0.53–12.17) | P = 0.241 | ns | 22 (45.8) | 1.38 (0.60–3.20) | P = 0.447 | ns |
 131RR | 9 (45.0) | 3.97 (0.83–19.10) | P = 0.085 | ns | 17 (35.4) | 1.67 (0.69–4.02) | P = 0.225 | ns |
Allele carriage | Â | Â | Â | Â | Â | Â | Â | Â |
 ≥1 131H allele | 11 (55.0) | 0.50 (0.20–1.26) | P = 0.143 | ns | 31 (64.6) | 0.75 (0.39–1.44) | P = 0.383 | ns |
 ≥1 131R allele | 18 (90.0) | 3.10 (0.70–13.77) | P = 0.136 | ns | 39 (81.3) | 1.49 (0.68–3.27) | P = 0.314 | ns |
FcγRIIb (rs1050501) |  |  | P = 0.125 | ns |  |  | P = 0.274 | ns |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â |
 232II (ref) | 10 (50.0) | 1 |  |  | 20 (41.7) | 1 |  |  |
 232IT | 6 (30.0) | 0.66 (0.23–1.87) | P = 0.434 | ns | 21 (43.8) | 1.15 (0.59–2.25) | P = 0.678 | ns |
 232TT | 4 (20.0) | 2.51 (0.71–8.87) | P = 0.153 | ns | 7 (14.6) | 2.20 (0.81–5.94) | P = 0.121 | ns |
Allele carriage | Â | Â | Â | Â | Â | Â | Â | Â |
 ≥1 232I allele | 16 (80.0) | 0.33 (0.10–1.10) | P = 0.072 | ns | 41 (85.4) | 0.49 (0.19–1.24) | P = 0.133 | ns |
 ≥1 232T allele | 10 (50.0) | 0.93 (0.37–2.33) | P = 0.883 | ns | 28 (58.3) | 1.31 (0.70–2.45) | P = 0.403 | ns |
FcγRIIIa (rs396991) |  |  | P = 0.137 | ns |  |  | P = 0.0004 | 0.017 |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â |
 158F/FF/FF (ref) | 11 (55.0) | 1 |  |  | 30 (62.5) | 1 |  |  |
 158FV/FFV/FVV | 8 (40.0) | 0.46 (0.18–1.19) | P = 0.108 | ns | 12 (25.0) | 0.25 (0.12–0.52) | P = 0.0001 | 0.004 |
 158V/VV | 1 (5.0) | 0.19 (0.02–1.50) | P = 0.115 | ns | 6 (12.5) | 0.41 (0.16–1.07) | P = 0.069 | ns |
Allele carriage | Â | Â | Â | Â | Â | Â | Â | Â |
 ≥1 158F allele | 19 (95.0) | 3.57 (0.46–27.48) | P = 0.222 | ns | 42 (87.5) | 1.31 (0.52–3.31) | P = 0.562 | ns |
 ≥1 158V allele | 9 (45.0) | 0.39 (0.16–0.99) | P = 0.048 | ns | 18 (37.5) | 0.29 (0.15–0.55) | P = 0.0001 | 0.004 |
FcγRIIIb |  |  | P = 0.320 | ns |  |  | P = 0.123 | ns |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â |
 HNA1a+/1b−/1c− | 6 (30.0) | 2.82 (0.67–11.82) | P = 0.155 | ns | 9 (18.8) | 0.79 (0.33–1.94) | P = 0.612 | ns |
 HNA1a−/1b+/1c− | 1 (5.0) | 1.04 (0.10–10.53) | P = 0.971 | ns | 3 (6.3) | 0.59 (0.16–2.20) | P = 0.429 | ns |
 HNA1a−/1b−/1c+ | 0 (0) | – |  |  | 0 (0) | – |  |  |
 HNA1a+/1b+/1c− (ref) | 3 (15.0) | 1 |  |  | 16 (33.3) | 1 |  |  |
 HNA1a+/1b−/1c+ | 4 (20.0) | 2.40 (0.51–11.26) | P = 0.267 | ns | 6 (12.5) | 0.68 (0.24–1.86) | P = 0.448 | ns |
 HNA1a−/1b+/1c+ | 5 (25.0) | 5.45 (1.21–24.66) | P = 0.028 | ns | 12 (25.0) | 2.45 (1.01–5.96) | P = 0.047 | ns |
 HNA1a+/1b+/1c+ | 1 (5.0) | 2.00 (0.19–20.85) | P = 0.562 | ns | 2 (4.2) | 0.75 (0.15–3.68) | P = 0.723 | ns |
Allele carriage | Â | Â | Â | Â | Â | Â | Â | Â |
 ≥1 HNA1a allotype | 14 (70.0) | 0.79 (0.29–2.14) | P = 0.638 | ns | 33 (68.8) | 0.74 (0.38–1.46) | P = 0.388 | ns |
 ≥1 HNA1b allotype | 10 (50.0) | 0.81 (0.33–2.03) | P = 0.659 | ns | 33 (68.8) | 1.79 (0.92–3.47) | P = 0.085 | ns |
 ≥1 HNA1c allotype | 10 (50.0) | 1.69 (0.68–4.22) | P = 0.262 | ns | 20 (41.7) | 1.21 (0.64–2.27) | P = 0.560 | ns |