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Table 2 FcγR genotypes and allele carriage in HIV-1 non-transmitting and transmitting mothers

From: Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility

 

Non-transmitting

Total transmitting

Intrapartum transmitting

N (%)

N (%)

OR (95 % CI)

P value

PBonf

N (%)

OR (95 % CI)

P value

PBonf

FcγRIIa (rs1801274)

Overall association

 

P = 0.379

ns

  

P = 0.688

ns

Genotype

         

 131HH (ref)

60 (25.6)

15 (19.0)

1

  

6 (19.4)

1

  

 131HR

106 (45.3)

36 (45.6)

1.36 (0.69–2.68)

P = 0.378

ns

14 (45.2)

1.32 (0.48–3.62)

P = 0.558

ns

 131RR

68 (29.1)

28 (35.4)

1.65 (0.80–3.37)

P = 0.172

ns

11 (35.5)

1.62 (0.56–4.64)

P = 0.371

ns

Allele carriage

         

 ≥1 131H allele

166 (70.9)

51 (64.6)

0.75 (0.43–1.28)

P = 0.288

ns

20 (64.5)

0.74 (0.34–1.64)

P = 0.464

ns

 ≥1 131R allele

174 (74.4)

64 (81.0)

1.47 (0.78–2.77)

P = 0.233

ns

25 (80.6)

1.44 (0.56–3.67)

P = 0.449

ns

FcγRIIb (rs1050501)

Overall association

 

P = 0.194

ns

  

P = 0.397

ns

Genotype

         

 232II (ref)

113 (48.3)

32 (40.5)

1

  

12 (38.7)

1

  

 232IT

103 (44.0)

36 (45.6)

1.23 (0.71–2.13)

P = 0.450

ns

15 (48.4)

1.37 (0.61–3.07)

P = 0.442

ns

 232TT

18 (7.7)

11 (13.9)

2.16 (0.93–5.03)

P = 0.075

ns

4 (12.9)

2.09 (0.61–7.20)

P = 0.242

ns

Allele carriage

         

 ≥1 232I allele

216 (92.3)

68 (86.3)

0.52 (0.23–1.14)

P = 0.103

ns

27 (87.1)

0.56 (0.18–1.79)

P = 0.239

ns

 ≥1 232T allele

121 (51.7)

47 (59.5)

1.37 (0.82–2.30)

P = 0.231

ns

19 (61.3)

1.48 (0.69–3.18)

P = 0.317

ns

FcγRIIIa (rs396991)

Overall association

 

P = 0.017

ns

  

P = 0.380

ns

Genotype

         

 158F/FF/FF (ref)

76 (32.5)

40 (50.6)

1

  

10 (32.3)

1

  

 158FV/FFV/FVV

121 (51.7)

31 (39.2)

0.49 (0.28–0.84)

P = 0.010

ns

19 (61.3)

1.19 (0.53–2.70)

P = 0.672

ns

 158V/VV

36 (15.4)

8 (10.1)

0.41 (0.17–0.97)

P = 0.041

ns

2 (6.5)

0.41 (0.09–1.97)

P = 0.266

ns

Allele carriage

         

 ≥1 158F allele

197 (84.2)

71 (89.9)

1.67 (0.74–3.75)

P = 0.217

ns

29 (93.5)

2.72 (0.62–11.91)

P = 0.183

ns

 ≥1 158V allele

157 (67.1)

39 (49.4)

0.47(0.28–0.79)

P = 0.004

ns

21 (67.7)

1.01 (0.45–2.25)

P = 0.980

ns

FcγRIIIb

Overall association

 

P = 0.058

ns

  

P = 0.647

ns

Genotype

         

 HNA1a+/1b−/1c−

51 (21.8)

13 (16.5)

0.68 (0.32–1.44)

P = 0.315

ns

4 (12.9)

0.51 (0.15–1.70)

P = 0.276

ns

 HNA1a−/1b+/1c−

23 (9.8)

7 (8.9)

0.81 (0.31–2.11)

P = 0.668

ns

4 (12.9)

1.14 (0.33–3.92)

P = 0.837

ns

 HNA1a−/1b−/1c+

13 (5.6)

0 (0)

–

  

0 (0)

–

  

 HNA1a+/1b+/1c− (ref)

72 (30.8)

27 (34.2)

1

  

11 (35.5)

1

  

 HNA1a+/1b−/1c+

40 (17.1)

11 (13.9)

0.73 (0.33–1.63)

P = 0.448

ns

5 (16.1)

0.82 (0.27–2.52)

P = 0.727

ns

 HNA1a−/1b+/1c+

22 (9.4)

17 (21.5)

2.06 (0.95–4.46)

P = 0.066

ns

5 (16.1)

1.49 (0.47–4.75)

P = 0.502

ns

 HNA1a+/1b+/1c+

12 (5.1)

4 (5.1)

0.89 (0.26–3.00)

P = 0.849

ns

2 (6.5)

1.09 (0.21–5.54)

P = 0.916

ns

Allele carriage

         

 ≥1 HNA1a allotype

175 (74.8)

55 (69.6)

0.77 (0.44–1.36)

P = 0.369

ns

22 (71.0)

0.82 (0.36–1.89)

P = 0.648

ns

 ≥1 HNA1b allotype

129 (55.1)

55 (69.6)

1.87 (1.08–3.21)

P = 0.025

ns

22 (71.0)

1.99 (0.88–4.50)

P = 0.099

ns

 ≥1 HNA1c allotype

87 (37.2)

32 (40.5)

1.15 (0.68–1.94)

P = 0.599

ns

12 (38.7)

1.07 (0.49–2.30)

P = 0.869

ns

 

In utero transmitting

In utero-enriched transmitting

 

N (%)

OR (95 % CI)

P value

PBonf

N (%)

OR (95 % CI)

P value

PBonf

FcγRIIa (rs1801274)

  

P = 0.182

ns

  

P = 0.545

ns

Genotype

        

 131HH (ref)

2 (10.0)

1

  

9 (18.8)

1

  

 131HR

9 (45.0)

2.55 (0.53–12.17)

P = 0.241

ns

22 (45.8)

1.38 (0.60–3.20)

P = 0.447

ns

 131RR

9 (45.0)

3.97 (0.83–19.10)

P = 0.085

ns

17 (35.4)

1.67 (0.69–4.02)

P = 0.225

ns

Allele carriage

        

 ≥1 131H allele

11 (55.0)

0.50 (0.20–1.26)

P = 0.143

ns

31 (64.6)

0.75 (0.39–1.44)

P = 0.383

ns

 ≥1 131R allele

18 (90.0)

3.10 (0.70–13.77)

P = 0.136

ns

39 (81.3)

1.49 (0.68–3.27)

P = 0.314

ns

FcγRIIb (rs1050501)

  

P = 0.125

ns

  

P = 0.274

ns

Genotype

        

 232II (ref)

10 (50.0)

1

  

20 (41.7)

1

  

 232IT

6 (30.0)

0.66 (0.23–1.87)

P = 0.434

ns

21 (43.8)

1.15 (0.59–2.25)

P = 0.678

ns

 232TT

4 (20.0)

2.51 (0.71–8.87)

P = 0.153

ns

7 (14.6)

2.20 (0.81–5.94)

P = 0.121

ns

Allele carriage

        

 ≥1 232I allele

16 (80.0)

0.33 (0.10–1.10)

P = 0.072

ns

41 (85.4)

0.49 (0.19–1.24)

P = 0.133

ns

 ≥1 232T allele

10 (50.0)

0.93 (0.37–2.33)

P = 0.883

ns

28 (58.3)

1.31 (0.70–2.45)

P = 0.403

ns

FcγRIIIa (rs396991)

  

P = 0.137

ns

  

P = 0.0004

0.017

Genotype

        

 158F/FF/FF (ref)

11 (55.0)

1

  

30 (62.5)

1

  

 158FV/FFV/FVV

8 (40.0)

0.46 (0.18–1.19)

P = 0.108

ns

12 (25.0)

0.25 (0.12–0.52)

P = 0.0001

0.004

 158V/VV

1 (5.0)

0.19 (0.02–1.50)

P = 0.115

ns

6 (12.5)

0.41 (0.16–1.07)

P = 0.069

ns

Allele carriage

        

 ≥1 158F allele

19 (95.0)

3.57 (0.46–27.48)

P = 0.222

ns

42 (87.5)

1.31 (0.52–3.31)

P = 0.562

ns

 ≥1 158V allele

9 (45.0)

0.39 (0.16–0.99)

P = 0.048

ns

18 (37.5)

0.29 (0.15–0.55)

P = 0.0001

0.004

FcγRIIIb

  

P = 0.320

ns

  

P = 0.123

ns

Genotype

        

 HNA1a+/1b−/1c−

6 (30.0)

2.82 (0.67–11.82)

P = 0.155

ns

9 (18.8)

0.79 (0.33–1.94)

P = 0.612

ns

 HNA1a−/1b+/1c−

1 (5.0)

1.04 (0.10–10.53)

P = 0.971

ns

3 (6.3)

0.59 (0.16–2.20)

P = 0.429

ns

 HNA1a−/1b−/1c+

0 (0)

–

  

0 (0)

–

  

 HNA1a+/1b+/1c− (ref)

3 (15.0)

1

  

16 (33.3)

1

  

 HNA1a+/1b−/1c+

4 (20.0)

2.40 (0.51–11.26)

P = 0.267

ns

6 (12.5)

0.68 (0.24–1.86)

P = 0.448

ns

 HNA1a−/1b+/1c+

5 (25.0)

5.45 (1.21–24.66)

P = 0.028

ns

12 (25.0)

2.45 (1.01–5.96)

P = 0.047

ns

 HNA1a+/1b+/1c+

1 (5.0)

2.00 (0.19–20.85)

P = 0.562

ns

2 (4.2)

0.75 (0.15–3.68)

P = 0.723

ns

Allele carriage

        

 ≥1 HNA1a allotype

14 (70.0)

0.79 (0.29–2.14)

P = 0.638

ns

33 (68.8)

0.74 (0.38–1.46)

P = 0.388

ns

 ≥1 HNA1b allotype

10 (50.0)

0.81 (0.33–2.03)

P = 0.659

ns

33 (68.8)

1.79 (0.92–3.47)

P = 0.085

ns

 ≥1 HNA1c allotype

10 (50.0)

1.69 (0.68–4.22)

P = 0.262

ns

20 (41.7)

1.21 (0.64–2.27)

P = 0.560

ns

  1. P values less than 0.05 are indicated in italics
  2. P Bonf Bonferroni corrected P value, OR odds ratio, CI confidence interval, ns not statistically significant, –, the variable of interest was not detected in any of the cases and thus could not be analysed