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Table 1 The rate of HIV-1 envelope gene sequence diversification with standard errors during the 150 days from the first sample in 15 subjects whose sequence data come from references [27, 3032]

From: Molecular clock of HIV-1 envelope genes under early immune selection

Subject Rate of linear diversification with standard errors (× 10−5 per base per day) p-value p-value for departure from the linear neutral ratea Rate of diversification in selection sites (× 10−5 per base per day) Rate of diversification in non-selection sites (× 10−5 per base per day)
CAP045 3.24 ± 0.56 <0.0001 0.073 8.74 ± 57.8 3.04 ± 0.50
CH040 1.54 ± 0.39 0.0013 0.13 47.3 ± 35.9 1.16 ± 0.35
CH042 1.96 ± 0.61 0.0061 0.74 28.2 ± 65.8 1.48 ± 0.55
CH058 2.91 ± 0.51 <0.0001 0.16 633.9 ± 50.6 2.03 ± 0.46
CH077 3.91 ± 0.42 <0.0001 0.00097 91.2 ± 39.8 3.09 ± 0.38
CH131 2.21 ± 0.38 <0.0001 0.90 27.1 ± 35.6 1.80 ± 0.34
CH159 2.57 ± 0.42 <0.0001 0.34 22.2 ± 39.4 2.21 ± 0.37
CH162 2.46 ± 0.53 0.0004 0.57 78.0 ± 53.2 1.89 ± 0.47
CH164 2.26 ± 0.64 0.0033 0.88 43.4 ± 71.9 1.83 ± 0.58
CH185 1.86 ± 0.57 0.0053 0.61 47.2 ± 59.0 1.51 ± 0.51
CH198 3.57 ± 0.62 <0.0001 0.039 50.4 ± 68.4 3.09 ± 0.56
CH256 3.58 ± 0.58 <0.0001 0.028 57.3 ± 61.0 2.77 ± 0.52
CH505 2.30 ± 0.27 <0.0001 0.60 45.4 ± 23.7 1.57 ± 0.24
SUMA0874 2.85 ± 0.78 0.0027 0.39 706.8 ± 109.8 2.17 ± 0.70
WEAU0578 3.17 ± 0.79 0.0013 0.22 190.8 ± 113.8 2.39 ± 0.71
Population mean 2.69 ± 0.29 N/A N/A 138.5 ± 61.7 2.13 ± 0.26
  1. aLess than 0.05 implies a statistically significant deviation from the neutral evolution rate, 2.16 × 10−5 per site per day