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Table 1 Comparison of RT and p24 assays for normalization of viral infectivity in TZM-bl cells

From: Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses

Genotype p24 assay RT assay
EC50 (ng p24) Relative fold decrease in infectivity 95 % Confidence intervals EC50 (cpm) Relative fold decrease in infectivity 95 % Confidence intervals
WT 3.57 1 2.77–4.58 3270 1 2545–4200
R263K 4.64 1.3* 3.68–5.84 3864 1.2* 3067–4868
H51Y/R263K 27.12 7.6*,$ 24.65–29.18 22,964 7*,$ 20,870–25,269
  1. *,$ Statistically significant difference from WT and R263K viruses, respectively (Student’s t test, P < 0.05)