Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses

Retrovirology

Table 1 Comparison of RT and p24 assays for normalization of viral infectivity in TZM-bl cells

Genotype	p24 assay			RT assay
Genotype	EC₅₀ (ng p24)	Relative fold decrease in infectivity	95 % Confidence intervals	EC₅₀ (cpm)	Relative fold decrease in infectivity	95 % Confidence intervals
WT	3.57	1	2.77–4.58	3270	1	2545–4200
R263K	4.64	1.3*	3.68–5.84	3864	1.2*	3067–4868
H51Y/R263K	27.12	7.6*^,$	24.65–29.18	22,964	7*^,$	20,870–25,269

*^,$ Statistically significant difference from WT and R263K viruses, respectively (Student’s t test, P < 0.05)

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